Polycomb group protein Ezh2 controls actin polymerization and cell signaling

被引：307

作者：

Su, I

Dobenecker, MW

Dickinson, E

Oser, M

Basavaraj, A

Marqueron, R

Viale, A

Reinberg, D

Wülfing, C

Tarakhovsky, A

机构：

[1] Rockefeller Univ, Lab Lymphoocyte Signaling, New York, NY 10021 USA

[2] Robert Wood Johnson Med Sch, Dept Biochem, Howard Hughes Med Inst, Div Nucle Acids Enzymol, Piscataway, NJ 08854 USA

[3] Mem Sloan Kettering Canc Ctr, Dept Mol Biol, Genom Core Lab, New York, NY 10021 USA

[4] Univ Texas, SW Med Ctr, Ctr Immunol, Dallas, TX 75390 USA

来源：

CELL | 2005年 / 121卷 / 03期

关键词：

D O I：

10.1016/j.cell.2005.02.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polycomb group protein Ezh2, one of the key regulators of development in organisms from flies to mice, exerts its epigenetic function through regulation of histone methylation. Here, we report the existence of the cytosolic Ezh2-containing methyltransferase complex and tie the function of this complex to regulation of actin polymerization in various cell types. Genetic evidence supports the essential role of cytosolic Ezh2 in actin polymerization-dependent processes such as antigen receptor signaling in T cells and PDGF-induced dorsal circular ruffle formation in fibroblasts. Revealed function of Ezh2 points to a broader usage of lysine methylation in regulation of both nuclear and extra-nuclear signaling processes.

引用

页码：425 / 436

页数：12

共 48 条

[1] T cell activation and the cytoskeleton [J].