Association between polymorphisms in the type 1 sigma receptor gene and schizophrenia

被引：61

作者：

Ishiguro, H

Ohtsuki, T

Toru, M

Itokawa, M

Aoki, J

Shibuya, H

Kurumaji, A

Okubo, Y

Iwawaki, A

Ota, K

Shimizu, H

Hamaguchi, H

Arinami, T ^{[1
]}

机构：

[1] Univ Tsukuba, Inst Basic Med Sci, Dept Med Genet, Tsukuba, Ibaraki 3058575, Japan

[2] Tokyo Med & Dent Univ, Sch Med, Dept Neuropsychiat, Tokyo 113, Japan

[3] Hokushin Gen Hosp, Dept Neuropsychiat, Nakano, Japan

来源：

NEUROSCIENCE LETTERS | 1998年 / 257卷 / 01期

关键词：

association; endoplasmic reticulum retention signal; gene; polymorphism; schizophrenia; sigma receptor;

D O I：

10.1016/S0304-3940(98)00797-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Several antipsychotic agents such as haloperidol and rimcazole are known to bind to sigma receptors with high affinity, and evidence for a potential link between sigma receptors and the etiology of schizophrenia has been reported. The present study was conducted to systematically search for nucleotide variants of the type 1 sigma receptor gene in 48 schizophrenics. Two polymorphisms were found: GC-241-240TT in the 5' flanking region and Gln2Pro. These two polymorphisms were in nearly complete linkage disequilibrium with each other. The Pro2 variant of the Gln2Pro polymorphism changes the endoplasmic reticulum retention signal motif. These polymorphisms were examined in an extended sample of schizophrenics (n =308) and controls (n = 433) and a significant association between the presence of the TT/Pro2 haplotype and schizophrenia was observed (odds ratio = 1.27, P = 0.04). (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：45 / 48

页数：4

共 13 条

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