Estrogen dependency in uterine endometrial cancers

被引：13

作者：

Fujimoto, J ^{[1
]}

Hirose, R ^{[1
]}

Sakaguchi, H ^{[1
]}

Tamaya, T ^{[1
]}

机构：

[1] Gifu Univ, Sch Med, Dept Obstet & Gynecol, Gifu 5008705, Japan

来源：

ONCOLOGY | 1998年 / 55卷

关键词：

estrogen dependence; estrogen receptor; endometrial cancer;

D O I：

10.1159/000055259

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Estrogen dependency in uterine endometrial cancers involves complicated tumor biology. A transformed phenotype of uterine endometrial cancers is supported by estrogen-dependent oncogene (c-Ha-rns, c-fos and c-jun) expressions. The relative overexpression of estrogen receptor exon 5 splicing variant and the damaged expression of progesterone receptor A, which belong to a lack of estrogen dependency, are related to metastatic potential. The estrogen-related metastatic processes, detachment, invasion and angiogenesis in some uterine endometrial cancers can be inhibited by progestins.

引用

页码：53 / 59

页数：7

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