Role of ATP hydrolysis by UvrA and UvrB during nucleotide excision repair

被引：56

作者：

Goosen, N ^{[1
]}

Moolenaar, GF ^{[1
]}

机构：

[1] Leiden Univ, Gorlaeus Labs, Leiden Inst Chem, Mol Genet Lab, NL-2300 RA Leiden, Netherlands

来源：

RESEARCH IN MICROBIOLOGY | 2001年 / 152卷 / 3-4期

关键词：

DNA repair; UvrABC; damage recognition; ABC signature; helicase motifs; ATP hydrolysis;

D O I：

10.1016/S0923-2508(01)01211-6

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Nucleotide excision repair in eubacteria is a process that repairs DNA damages by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-dependent reaction that requires the UvrA, UvrB and UvrC proteins. Both UvrA and UvrB are ATPases, with UvrA having two ATP binding sites which have the characteristic signature of the family of ABC proteins and UvrB having one ATP binding site that is structurally related to that of helicases. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

引用

页码：401 / 409

页数：9

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