Study of the intronic polymorphism of the angiotensin 1 converting enzyme among coronary Tunisians

被引：5

作者：

Chalghoum, A. ^{[1
]}

Noichri, Y. ^{[1
]}

Chkioua, L. ^{[1
]}

Gammoudi, I. ^{[1
]}

Dandana, A. ^{[1
]}

Chahed, H. ^{[1
]}

Khelil, S. ^{[1
]}

Jeridi, G. ^{[2
]}

Baudin, B. ^{[3
]}

Ferchichi, S. ^{[1
]}

Miled, A. ^{[1
]}

机构：

[1] CHU Farhat Hached, Serv Biochim, Biochim Lab, Sousse 4000, Tunisia

[2] CHU Farhat Hached, Serv Cardiol, Sousse 4000, Tunisia

[3] Hop St Antoine, Serv Biochim A, F-75571 Paris 12, France

来源：

ANNALES DE CARDIOLOGIE ET D ANGEIOLOGIE | 2011年 / 60卷 / 03期

关键词：

Acute coronary syndromes (ACS); Angiotensin I converting enzyme (ACED; Genetic predisposition; Intronic deletion; GENE POLYMORPHISMS; ARTERY-DISEASE; RISK;

D O I：

10.1016/j.ancard.2010.12.019

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Background. - The acute coronary syndromes (ACS) are classified among the major causes of mortality in the industrialized countries. The increased angiotensin I converting enzyme (ACEI) activity related to a genetic polymorphism constitutes a hereditary predisposition to these syndromes. Aim. - Evaluate the ACEI activity in Tunisian patients with coronary heart disease, and investigate the association between this activity and an intronic deletion of 287 pb on the introit 16 of the ACEI gene. Patients and methods. - Seventy-two coronary patients and 34 control subjects are recruited for our study. ACEI activity was measured by kinetic method. The intronic deletion was identified by PCR technique. Results. An increased activity of ACEI was observed in patients compared with control subjects (84.38 +/- 33.83 Ul/L vs 59.06 +/- 18.2 Ul/L, P=10(-5)). The molecular study showed a raised relative frequency of DID genotype (51.4%) among patients, whereas among the witnesses, 111 genotype prevailed (62%). DID genotype is always associated with highest ACEI activity for the patients and the control subjects. Conclusion. The molecular studies and the biochemical investigations of the various parameters of cardiovascular risk (including the ACEI) direct towards a better treatment. (C) 2011 Elsevier Masson SAS. All rights reserved.

引用

页码：135 / 140

页数：6

共 28 条

[1]

Akoudad H., 2004, EMC - Cardiologie-Angeiologie, V1, P49

[2]

Angiotensin I-converting enzyme (ACE) for sarcoidosis diagnosis [J].

Baudin, B .

PATHOLOGIE BIOLOGIE, 2005, 53 (03) :183-188

[3]

New aspects on angiotensin-converting enzyme: From gene to disease [J].

Baudin, B .

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2002, 40 (03) :256-265

[4]

Angiotensin I-converting enzyme gene polymorphism and drug response [J].

Baudin, B .

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2000, 38 (09) :853-856

[5]

BAUDIN B, 2005, IMMUNOANAL BIOL SPEC, V20, P161

[6]

Beaudeux J-L, 2006, IMMUNO-ANAL BIOL SPE, V21, P144, DOI DOI 10.1016/J.IMMBIO.2006.02.001

[7]

Benamer H, 2001, Ann Cardiol Angeiol (Paris), V50, P357, DOI 10.1016/S0003-3928(01)00041-5

[8]

Bennouar N, 2004, ANN BIOL CLIN-PARIS, V62, P295

[9]

Brendan C, 2003, ANN CARDIOVASC PATHO, V12, P237

[10]

Angiotensin AT2 receptors:: control of renal sodium excretion and blood pressure [J].

Carey, Robert M. ;

Padia, Shetal H. .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2008, 19 (03) :84-87

← 1 2 3 →