The anti-inflammatory properties of halloysite

被引：31

作者：

Cornejo-Garrido, Hilda

Nieto-Camacho, Antonio ^{[4
]}

Gomez-Vidales, Virginia ^{[4
]}

Teresa Ramirez-Apan, Maria ^{[4
]}

del Angel, Paz

Ascencion Montoya, Jose

Dominguez-Lopez, Mariana ^{[5
]}

Kibanova, Dania ^{[1
]}

Cervini-Silva, Javiera ^{[1
,2
,3
]}

机构：

[1] Univ Autonoma Metropolitana, Dept Proc & Tecnol, Unidad Cuajimalpa, Mexico City 01120, DF, Mexico

[2] NASA, Astrobiol Inst, Washington, DC USA

[3] Lawrence Berkeley Natl Lab, Div Earth Sci, Berkeley, CA USA

[4] Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico

[5] Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Mexico City 04510, DF, Mexico

来源：

APPLIED CLAY SCIENCE | 2012年 / 57卷

关键词：

Vehicle-delivery drugs; lndomethacin; Naturally-occurring; Clays; Inexpensive; LIPID-PEROXIDATION; OXIDATIVE STRESS; NITRIC-OXIDE; MOUSE EAR; CHEMISTRY; MACROPHAGES; SUSPENSIONS; PARTICLES; TISSUES; AGENTS;

D O I：

10.1016/j.clay.2011.12.001

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

Halloysite can serve as an alternative agent for drug delivery because its production is not tedious, hazardous, or expensive. In this study we show that halloysite presented anti-inflammatory properties comparable to indomethacin as evidenced by determination of the mieloperoxidase (MPO) enzymatic activity, a specific marker for migration and cellular infiltration. Edema reached maximum levels after 4 h. Cellular migration was noted to be low. After 24 h, however, cellular migration was noted to increase. Experiments conducted with mice primary peritoneal macrophages showed that halloysite (vs aminoguanidine) inhibited the production of nitric oxide. Halloysite inhibited oxidative stress via lipid peroxidation (ca. IC50 = 2023 ppm). (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：10 / 16

页数：7

共 39 条

[1]

Role of nitric oxide in mediation of macrophage cytotoxicity and apoptosis [J].

Albina, JE ;

Reichner, JS .

CANCER AND METASTASIS REVIEWS, 1998, 17 (01) :39-53

[2]

EPIDEMIOLOGIC AND ENVIRONMENTAL EVIDENCE OF THE HEALTH-EFFECTS OF EXPOSURE TO ERIONITE FIBERS - A 4-YEAR STUDY IN THE CAPPADOCIAN REGION OF TURKEY [J].

BARIS, I ;

SIMONATO, L ;

ARTVINLI, M ;

POOLEY, F ;

SARACCI, R ;

SKIDMORE, J ;

WAGNER, C .

INTERNATIONAL JOURNAL OF CANCER, 1987, 39 (01) :10-17

[3]

BATES TF, 1959, AM MINERAL, V44, P78

[4]

Role of transition metals, Fe(II), Cr(II), Pb(II), and Cd(II) in lipid peroxidation [J].

Benedet, J. A. ;

Shibamoto, T. .

FOOD CHEMISTRY, 2008, 107 (01) :165-168

[5]

ANTIOXIDANT DETERMINATIONS BY THE USE OF A STABLE FREE RADICAL [J].

BLOIS, MS .

NATURE, 1958, 181 (4617) :1199-1200

[6]

MEASUREMENT OF CUTANEOUS INFLAMMATION - ESTIMATION OF NEUTROPHIL CONTENT WITH AN ENZYME MARKER [J].

BRADLEY, PP ;

PRIEBAT, DA ;

CHRISTENSEN, RD ;

ROTHSTEIN, G .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1982, 78 (03) :206-209

[7]

INVITRO CORRELATES OF MINERAL DUST TOXICITY [J].

BROWN, RC ;

POOLE, A ;

TURVER, CJ .

FOOD AND CHEMICAL TOXICOLOGY, 1986, 24 (6-7) :535-538

[8]

Oxidative stress, cytoxicity, and cell mortality induced by nano-sized lead in aqueous suspensions [J].

Cornejo-Garrido, Hilda ;

Kibanova, Daria ;

Nieto-Camacho, Antonio ;

Guzman, Jose ;

Ramirez-Apan, Teresa ;

Fernandez-Lomelin, Pilar ;

Laura Garduno, Maria ;

Cervini-Silva, Javiera .

CHEMOSPHERE, 2011, 84 (10) :1329-1335

[9]

DAVIES D, 1983, BRIT J IND MED, V40, P22

[10]

DEYOUNG LM, 1989, AGENTS ACTIONS, V26, P335

← 1 2 3 4 →