HIV evolution in response to HLA-restricted CTL selection pressures: a population-based perspective

被引：45

作者：

Carlson, Jonathan M. ^{[2
,3
]}

Brumme, Zabrina L. ^{[1
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Partners AIDS Res Ctr, Boston, MA 02115 USA

[2] Microsoft Res, Redmond, WA USA

[3] Univ Washington, Dept Comp Sci & Engn, Seattle, WA 98195 USA

来源：

MICROBES AND INFECTION | 2008年 / 10卷 / 05期

关键词：

human immunodeficiency virus; human leukocyte antigen; cytotoxic T lymphocytes; immune escape; viral evolution; vaccine;

D O I：

10.1016/j.micinf.2008.01.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytotoxic T lymphocytes (CTL) recognize antigenic peptides displayed by HLA class I molecules on the infected cell surface and represent a major selective force driving HIV evolution through a phenomenon known as "immune escape". Here we summarize recent advances in our understanding of the consequences of CTL escape on HIV evolution at the population level and discuss its implications for HIV vaccine design. (C) 2008 Elsevier Masson SAS. All rights reserved.

引用

页码：455 / 461

页数：7

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