Vascular remodeling versus vasoconstriction in chronic hypoxic pulmonary hypertension - A time for reappraisal?

被引:122
作者
Stenmark, KR
McMurtry, IF
机构
[1] Univ Colorado, Hlth Sci Ctr, Dev Lung Biol Lab, Denver, CO 80262 USA
[2] Univ Colorado, Hlth Sci Ctr, Cardiovasc Pulm Res Lab, Denver, CO 80262 USA
关键词
pulmonary hypertension; hypoxia; vascular remodeling; Rho kinase; angiogenesis;
D O I
10.1161/01.RES.00000175934.68087.29
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:95 / 98
页数:4
相关论文
共 40 条
[1]   Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats [J].
Abe, K ;
Shimokawa, H ;
Morikawa, K ;
Uwatoku, T ;
Oi, K ;
Matsumoto, Y ;
Hattori, T ;
Nakashima, Y ;
Kaibuchi, K ;
Sueishi, K ;
Takeshita, A .
CIRCULATION RESEARCH, 2004, 94 (03) :385-393
[2]   Pulmonary hypertension in chronic obstructive pulmonary disease [J].
Barberà, JA ;
Peinado, VI ;
Santos, S .
EUROPEAN RESPIRATORY JOURNAL, 2003, 21 (05) :892-905
[3]   BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia [J].
Beppu, H ;
Ichinose, F ;
Kawai, N ;
Jones, RC ;
Yu, PB ;
Zapol, WM ;
Miyazono, K ;
Li, E ;
Bloch, KD .
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2004, 287 (06) :L1241-L1247
[4]  
Bishop J.E., 1995, PULMONARY VASCULAR R, P47
[5]   Arterial structural changes in hypertension: A consideration of methodology, terminology and functional consequence [J].
Bund, SJ ;
Lee, RMKW .
JOURNAL OF VASCULAR RESEARCH, 2003, 40 (06) :547-557
[6]   Enhanced expression of inducible nitric oxide synthase without vasodilator effect in chronically infected lungs [J].
Cadogan, E ;
Hopkins, N ;
Giles, S ;
Bannigan, JG ;
Moynihan, J ;
McLoughlin, P .
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 1999, 277 (03) :L616-L627
[7]  
CLOZEL JP, 1991, J CARDIOVASC PHARM, V17, P36, DOI 10.1097/00005344-199101000-00006
[8]   PROGRESSIVE LOSS OF VASODILATOR RESPONSIVE COMPONENT OF PULMONARY-HYPERTENSION IN NEONATAL CALVES EXPOSED TO 4,570 M [J].
DURMOWICZ, AG ;
ORTON, EC ;
STENMARK, KR .
AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 265 (06) :H2175-H2183
[9]   MECHANICAL-PROPERTIES AND REACTIVITY OF VESSELS IN ISOLATED PERFUSED LUNGS OF CHRONICALLY HYPOXIC RATS [J].
EMERY, CJ ;
BEE, D ;
BARER, GR .
CLINICAL SCIENCE, 1981, 61 (05) :569-580
[10]   Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase [J].
Fagan, KA ;
Oka, M ;
Bauer, NR ;
Gebb, SA ;
Ivy, DD ;
Morris, KG ;
McMurtry, IF .
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2004, 287 (04) :L656-L664