Response to rituximab in a child with neuroblastoma and opsoclonus-myoclonus

被引：23

作者：

Bell, Jessica ^{[1
]}

Moran, Cassandra ^{[1
]}

Blatt, Julie ^{[1
]}

机构：

[1] Univ N Carolina, Sch Med, Dept Pediat, Div Pediat Hematol Oncol, Chapel Hill, NC 27599 USA

来源：

PEDIATRIC BLOOD & CANCER | 2008年 / 50卷 / 02期

关键词：

neuroblastoma; opsoclonus-myoclonus; rituximab;

D O I：

10.1002/pbc.20899

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Opsoclonus-myoclonus (OM) is a paraneoplastic syndrome of probable autoimmune origin. Despite current therapies aimed at decreasing autoantibody formation, OM is difficult to control and may impact long-term neurologic outcome. We present a case of a 19-month-old patient who initially presented with OM, neuro-blastoma and a constitutional cytogenetic abnormality t(5;12) (q11.2;q15). The patient's OM was recalcitrant to conventional therapies, but showed significant improvement following treatment with rituximab. Pediatr Blood Cancer 2008;50:370-371. (c) 2006 Wiley-Liss, Inc.

引用

页码：370 / 371

页数：2

共 20 条

[1] Antineuronal antibodies in patients with neuroblastoma and paraneoplastic opsoclonus-myoclonus [J].

Antunes, NL ;

Khakoo, Y ;

Matthay, KK ;

Seeger, RC ;

Stram, DO ;

Gerstner, E ;

Abrey, LE ;

Dalmau, J .

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2000, 22 (04) :315-320

[2] Paraneoplastic opsoclonus-myoclonus secondary to malignant melanoma [J].

Berger, JR ;

Mehari, E .

JOURNAL OF NEURO-ONCOLOGY, 1999, 41 (01) :43-45

[3] Rituximab therapy for multisystem autoimmune diseases in pediatric patients [J].

Binstadt, BA ;

Caldas, AMC ;

Turvey, SE ;

Weinstein, HJ ;

Jackson, J ;

Fuhlbrigge, RC ;

Sundel, RP .

JOURNAL OF PEDIATRICS, 2003, 143 (05) :598-604

[4] ANTI-HU ANTIBODY IN A NEUROBLASTOMA-ASSOCIATED PARANEOPLASTIC-SYNDROME [J].

FISHER, PG ;

WECHSLER, DS ;

SINGER, HS .

PEDIATRIC NEUROLOGY, 1994, 10 (04) :309-312

[5] SELECTIVE EXPRESSION OF PURKINJE-CELL ANTIGENS IN TUMOR-TISSUE FROM PATIENTS WITH PARANEOPLASTIC CEREBELLAR DEGENERATION [J].

FURNEAUX, HM ;

ROSENBLUM, MK ;

DALMAU, J ;

WONG, E ;

WOODRUFF, P ;

GRAUS, F ;

POSNER, JB .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (26) :1844-1851

[6] Long-term neurobehavioral outcomes in children with neuroblastoma and opsoclonus-myoclonus-ataxia syndrome: Relationship to MRI findings and anti-neuronal antibodies [J].

Hayward, K ;

Jeremy, RJ ;

Jenkins, S ;

Barkovich, AJ ;

Gultekin, SH ;

Kramer, J ;

Crittenden, M ;

Matthay, KK .

JOURNAL OF PEDIATRICS, 2001, 139 (04) :552-559

[7] PARANEOPLASTIC OPSOCLONUS-MYOCLONUS IN HODGKINS-DISEASE [J].

KAY, CL ;

DAVIESJONES, GAB ;

SINGAL, R ;

WINFIELD, DA .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1993, 56 (07) :831-832

[8] Paraneoplastic Opsoclonus-Myoclonus Syndrome: initial presentation of non-Hodgkins lymphoma [J].

Kumar, A ;

Lajara-Nanson, WA ;

Neilson, RW .

JOURNAL OF NEURO-ONCOLOGY, 2005, 73 (01) :43-45

[9] Longitudinal neurodevelopmental evaluation of children with opsoclonus-ataxia [J].

Mitchell, WG ;

Brumm, VL ;

Azen, CG ;

Patterson, KE ;

Aller, SK ;

Rodriguez, J .

PEDIATRICS, 2005, 116 (04) :901-907

[10] Opsoclonus-myoclonus syndrome: Gabapentin as a new therapeutic proposal [J].

Moretti, R ;

Torre, P ;

Antonello, RM ;

Nasuelli, D ;

Cazzato, G .

EUROPEAN JOURNAL OF NEUROLOGY, 2000, 7 (04) :455-456

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