学术探索
学术期刊
学术作者
新闻热点
数据分析
智能评审

Myosins: Tails (and heads) of functional diversity

被引：283
作者：
Krendel, M [1 ]
Mooseker, MS
机构：
[1] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA
[2] Yale Univ, Dept Cell Biol, New Haven, CT USA
[3] Yale Univ, Dept Pathol, New Haven, CT USA
来源：
PHYSIOLOGY | 2005年 / 20卷
关键词：
D O I：
10.1152/physiol.00014.2005
中图分类号：
Q4 [生理学];
学科分类号：
071003 [生理学];
摘要：
The myosin family of actin filament-based molecular motors consists of at least 20 structurally and functionally distinct classes. The human genome contains nearly 40 myosin genes, encoding 12 of these classes. Myosins have been implicated in a variety of intracellular functions, including cell migration and adhesion; intracellular transport and localization of organelles and macromolecules; signal transduction; and tumor suppression. In this review, recent insights into the remarkable diversity in the mechanochemical and functional properties associated with this family of molecular motors are discussed.
引用
收藏
页码：239 / 251
页数：13
相关论文
共 159 条
[1]
Interactions in the network of Usher syndrome type 1 proteins [J].
Adato, A ;
Michel, V ;
Kikkawa, Y ;
Reiners, J ;
Alagramam, KN ;
Weil, D ;
Yonekawa, H ;
Wolfrum, U ;
El-Amraoui, A ;
Petit, C .
HUMAN MOLECULAR GENETICS, 2005, 14 (03) :347-356
[2]
The mechanism of myosin VI translocation an its load-induced anchoring [J].
Altman, D ;
Sweeney, HL ;
Spudich, JA .
CELL, 2004, 116 (05) :737-749
[3]
Uncoated endocytic vesicles require the unconventional myosin, Myo6, for rapid transport through actin barriers [J].
Aschenbrenner, L ;
Naccache, SN ;
Hasson, T .
MOLECULAR BIOLOGY OF THE CELL, 2004, 15 (05) :2253-2263
[4]
Myo6 facilitates the translocation of endocytic vesicles from cell peripheries [J].
Aschenbrenner, L ;
Lee, T ;
Hasson, T .
MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (07) :2728-2743
[5]
Myosins on the move to signal transduction [J].
Bahler, M .
CURRENT OPINION IN CELL BIOLOGY, 1996, 8 (01) :18-22
[6]
Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia [J].
Belyantseva, IA ;
Boger, ET ;
Naz, S ;
Frolenkov, GI ;
Sellers, JR ;
Ahmed, ZM ;
Griffith, AJ ;
Friedman, TB .
NATURE CELL BIOLOGY, 2005, 7 (02) :148-U60
[7]
Dimerization of the highly conserved light chain shared by dynein and myosin V [J].
Benashski, SE ;
Harrison, A ;
PatelKing, RS ;
King, SM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (33) :20929-20935
[8]
A millennial myosin census [J].
Berg, JS ;
Powell, BC ;
Cheney, RE .
MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (04) :780-794
[9]
Bielinska M, 1999, INT J DEV BIOL, V43, P183
[10]
Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle [J].
Boëda, B ;
El-Amraoui, A ;
Bahloul, A ;
Goodyear, R ;
Daviet, L ;
Blanchard, S ;
Perfettini, I ;
Fath, KR ;
Shorte, S ;
Reiners, J ;
Houdusse, A ;
Legrain, P ;
Wolfrum, U ;
Richardson, G ;
Petit, C .
EMBO JOURNAL, 2002, 21 (24) :6689-6699
12345678910