Overproduction of PU.1 in mast cell progenitors: its effect on monocyte- and mast cell-specific gene expression

被引：22

作者：

Nishiyama, C

Nishiyama, M

Ito, T

Masaki, S

Maeda, K

Masuoka, N

Yamane, H

Kitamura, T

Ogawa, H

Okumura, K

机构：

[1] Juntendo Univ, Sch Med, Atopy Allergy Res Ctr, Bunkyo Ku, Tokyo 1138421, Japan

[2] Univ Tokyo, Inst Med Sci, Div Cellular Therapy, Minato Ku, Tokyo 1088639, Japan

[3] Univ Tokyo, Biotechnol Res Ctr, Bunkyo Ku, Tokyo 1138657, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 313卷 / 03期

关键词：

mast cells; monocyte; MHC class II; PU.1; transcription factor;

D O I：

10.1016/j.bbrc.2003.11.145

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Ets family transcription factor PU.1 is required for development of various lymphoid and myeloid cell lineages, and regulates the expression of several genes in a cell type-specific manner. Mouse bone marrow-derived hematopoietic progenitor cells are programmed to differentiate into mast cells, when the cells are maintained in the presence of pokeweed mitogen-stimulated spleen-conditioned medium. However, by retroviral introduction of PU.1 cDNA, the progenitor cells expressed MHC class II, CD11b, CD11c, and F4/80, and acquired the ability to stimulate T cells. Furthermore, PU.1-overproducing cells exhibited the morphology, in part, similar to that of monocyte. These results indicate that the mast cell progenitors still have the ability to express monocyte-specific genes by increased expression of PU.1. (C) 2003 Elsevier Inc. All rights reserved.

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收藏

页码：516 / 521

页数：6

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