Hypointense signals in the infrapatellar fat pad assessed by magnetic resonance imaging are associated with knee symptoms and structure in older adults: a cohort study

被引:60
作者
Han, Weiyu [1 ,2 ]
Aitken, Dawn [1 ]
Zhu, Zhaohua [1 ,3 ]
Halliday, Andrew [4 ]
Wang, Xia [1 ]
Antony, Benny [1 ]
Cicuttini, Flavia M. [5 ]
Jones, Graeme [1 ]
Ding, Changhai [1 ,3 ,5 ]
机构
[1] Univ Tasmania, Menzies Inst Med Res, Private Bag 23, Hobart, Tas 7000, Australia
[2] Southern Med Univ, Dept Orthoped, Affiliated Hosp 3, Guangzhou, Guangdong, Peoples R China
[3] Anhui Med Univ, Arthrit Res Inst, Affiliated Hosp 1, Hefei, Anhui, Peoples R China
[4] Royal Hobart Hosp, Dept Radiol, Hobart, Tas, Australia
[5] Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic, Australia
基金
英国医学研究理事会;
关键词
Infrapatellar fat pad; Osteoarthritis; Signal intensity; Cartilage defects; Bone marrow lesions; Pain; EARLY RADIOGRAPHIC OSTEOARTHRITIS; CARTILAGE VOLUME; SCORING SYSTEM; SURFACE-AREA; SYNOVITIS; PAIN; MRI; DEFECTS; MODEL; ARTHRITIS;
D O I
10.1186/s13075-016-1130-y
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Background: There are few clinical and epidemiological studies reporting the association between abnormal changes within the IPFP and knee osteoarthritic changes. This study aims to describe the associations between hypointense signals in the infrapatellar fat pad (IPFP) and knee structural change and symptoms in older adults. Methods: Participants (n = 874) were selected randomly from local community and followed up 2.7 years later (range 2.6-3.3 years). T1- or T2-weighted fat-suppressed magnetic resonance imaging (MRI) was assessed for IPFP hypointense signal, cartilage volume, cartilage defects, and bone marrow lesions (BMLs). Knee pain was assessed by self-administered Western Ontario and McMaster Osteoarthritis Index (WOMAC) questionnaire. Radiographic osteoarthritis was assessed using the OARSI atlas. Results: Cross-sectionally, hypointense signals in the IPFP were significantly associated with a higher risk of knee cartilage defects at all sites, tibiofemoral BMLs and knee pain in multivariable analyses. Longitudinally, baseline signal abnormalities were significantly and positively associated with increases in knee cartilage defects (OR: 2.27, 95 % CI: 1.61-3.21), BMLs (OR: 1.91, 95 % CI: 1.39-2.62), and knee pain (OR: 1.36, 95 % CI: 1.05-1.76) in multivariable analyses. The associations with cartilage defects remained significant after adjustment for BMLs, but the associations with BMLs and knee pain decreased in magnitude or became non-significant after further adjustment for cartilage defects. Conclusions: Hypointense signals in the IPFP were associated primarily with increased knee cartilage defects and also with BMLs and knee symptoms in cross-sectional and longitudinal analyses, suggesting the abnormality represented by this signal has a potentially important role in osteoarthritis progression.
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页数:9
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