Production of tumor necrosis factor and nitric oxide by macrophages infected with live and dead mycobacteria and their suppression by an interleukin-10-secreting recombinant

被引：37

作者：

Marshall, BG

Chambers, MA

Wangoo, A

Shaw, RJ

Young, DB

机构：

[1] ST MARYS HOSP,IMPERIAL COLL,SCH MED,DEPT RESP MED,LONDON W2 1PG,ENGLAND

[2] ST MARYS HOSP,IMPERIAL COLL,SCH MED,DEPT MED MICROBIOL,LONDON W2 1PG,ENGLAND

来源：

INFECTION AND IMMUNITY | 1997年 / 65卷 / 05期

关键词：

D O I：

10.1128/IAI.65.5.1931-1935.1997

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have analyzed mycobacterium-induced cytokine secretion in the J774A.1 macrophage-like cell line. Tumor necrosis factor alpha (TNF-alpha) was preferentially induced by live organisms, both slow and rapid growing. Expression of interleukin-10 by a recombinant strain of Mycobacterium smegmatis caused reduced production of TNF-alpha and nitric oxide during the early stages of infection.

引用

页码：1931 / 1935

页数：5

共 50 条

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BARNES PF, 1992, J IMMUNOL, V149, P541

[2]

BEHLING CA, 1993, ANN CLIN LAB SCI, V23, P256

[3]

Chambers MA, 1997, J IMMUNOL, V158, P1742

[4] KILLING OF VIRULENT MYCOBACTERIUM-TUBERCULOSIS BY REACTIVE NITROGEN INTERMEDIATES PRODUCED BY ACTIVATED MURINE MACROPHAGES [J].