HLA and AIDS: a cautionary tale

被引：181

作者：

O'Brien, SJ ^{[1
]}

Gao, XJ

Carrington, M

机构：

[1] NCI, Lab Genom Divers, Frederick, MD 21702 USA

[2] NCI, SAIC Frederick, Intramural Res Support Program, Frederick, MD 21702 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2001年 / 7卷 / 09期

关键词：

D O I：

10.1016/S1471-4914(01)02131-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human major histocompatibility complex HLA has been implicated repeatedly as a regulator of the outcome of HIV exposure and infection. A new study of long-term survivors who naturally depress HIV-1 replication and avoid the signs of AIDS for years after infection suggests that homozygosity for a group of HLA-B locus alleles termed Bw4 confers resistance, ostensibly by regulating natural killer cell-ligand interactions. However, close inspection of the accumulated evidence raises some questions and urges validation of the potential Bw4 effects in additional studies.

引用

页码：379 / 381

页数：3

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