Two novel biallelic polymorphisms in the IL-2 gene

被引：82

作者：

John, S

Turner, D

Donn, R

Sinnott, P

Worthington, J

Ollier, WER

Hutchinson, IV

Hajeer, AH

机构：

[1] ARC Epidemiol Res Unit, Manchester M13 9PT, Lancs, England

[2] Natl Blood Serv, N London Ctr, London NW9 5BG, England

[3] Sch Biol Sci, Immunol Grp, Manchester M13 9PT, Lancs, England

[4] Royal London Hosp, London E1 1BB, England

来源：

EUROPEAN JOURNAL OF IMMUNOGENETICS | 1998年 / 25卷 / 06期

关键词：

D O I：

10.1046/j.1365-2370.1998.00139.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have detected two novel single nucleotide polymorphisms in the IL-2 gene, at positions -330 and +166 relative to the transcription start site. The +166 change occurs within the leader peptide and does not affect amino acid sequence. The -330 polymorphism has two common alleles, making it an ideal marker for genetic association studies.

引用

页码：419 / 420

页数：2

共 5 条

[1] Mapping of the IDDM locus Idd3 to a 0.35-cM interval containing the interleukin-2 gene [J].