Clinico-hematologic profile of factor XIII-deficient patients

被引：12

作者：

Bhattacharya, M ^{[1
]}

Biswas, A ^{[1
]}

Ahmed, RPH ^{[1
]}

Karman, M ^{[1
]}

Gupta, M ^{[1
]}

Mahapatra, M ^{[1
]}

Choudhry, VP ^{[1
]}

Saxena, R ^{[1
]}

机构：

[1] All India Inst Med Sci, Dept Haematol, New Delhi 110029, India

来源：

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS | 2005年 / 11卷 / 04期

关键词：

prothrombin time; hematoma; recurrent abortion; intracranial hemorrhage;

D O I：

10.1177/107602960501100416

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A retrospective analysis of clinico-hematologic parameters of 18 factor XIII-deficient patients was carried out. The hematologic tests included activated partial thromboplastin time (APTT), prothrombin time (PT), and clot solubility. Laboratory diagnosis of FXIII deficiency was made where bleeding time, PT, APTT, and thrombin time were normal and the clot solubility test result with 5M urea was positive. Factor XIII level with family screening bleeding from the umbilical stump was present in four (22.2%) patients. The most common site of bleeding was the skin (11 of 18 patients). Three patients were given prophylaxis (FFP in two, factor XIII in one). A high prevalence of recurrent abortion in female patients with FXIII deficiency (two of the three patients in this study) was observed.

引用

页码：475 / 480

页数：6

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