Controlled trial of N-acetyleysteine for patients with probable Alzheimer's disease

被引：185

作者：

Adair, JC

Knoefel, JE

Morgan, N

机构：

[1] Univ New Mexico, Sch Med, Dept Neurol, Albuquerque, NM 87131 USA

[2] Vet Affairs Med Ctr, Neurol Serv, Albuquerque, NM USA

[3] Vet Affairs Med Ctr, Geriatr Serv, Albuquerque, NM USA

[4] Univ New Mexico, Dept Internal Med, Albuquerque, NM 87131 USA

[5] Vet Affairs Cooperat Studies Pharm, Albuquerque, NM USA

来源：

NEUROLOGY | 2001年 / 57卷 / 08期

关键词：

D O I：

10.1212/WNL.57.8.1515

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The antioxidant N-acetylcysteine (NAG) or placebo was administered in a double-blind fashion to patients who met National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association criteria for probable AD. Testing for efficacy occurred after 3 and 6 months of treatment. Comparison of interval change favored NAC treatment on nearly every outcome measure, although significant differences were obtained only for a subset of cognitive tasks.

引用

页码：1515 / 1517

页数：3

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