Spherically averaged phased translation function and its application to the search for molecules and fragments in electron-density maps

被引：201

作者：

Vagin, AA ^{[1
]}

Isupov, MN

机构：

[1] Univ York, Dept Chem, York YO1 5DD, N Yorkshire, England

[2] Univ Exeter, Sch Chem, Exeter EX4 4QD, Devon, England

来源：

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY | 2001年 / 57卷

关键词：

D O I：

10.1107/S0907444901012409

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The molecular-replacement method has been extended to locate molecules and their fragments in an electron-density map. The approach is based on a new spherically averaged phased translation function. The position of the centre of mass of a search model is found prior to determination of its orientation. The orientation is subsequently found by a phased rotation function. The technique also allows superposition of distantly related macromolecules. The method has been implemented in a computer program MOLREP and successfully tested using experimental data sets.

引用

页码：1451 / 1456

页数：6

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