Differential G-protein coupling to GABAB receptor in limbic areas of alcohol-preferring and -nonpreferring rats

被引：9

作者：

Castelli, MP ^{[1
]}

Pibiri, F

Piras, AP

Carboni, G

Orrù, A

Gessa, GL

Carai, MAM

Colombo, G

机构：

[1] Univ Cagliari, Bernard B Brodie Dept Neurosci, Cittadella Univ Monserrato, I-09042 Monserrato, Italy

[2] CNR, Inst Neurosci, Cagliari, Italy

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2005年 / 523卷 / 1-3期

关键词：

GABA(B) receptor; S-35]GTP gamma S binding; voluntary alcohol consumption; (sP) Sardinian alcohol-preferring and (sNP) Sardinian alcohol-nonpreferring (rat);

D O I：

10.1016/j.ejphar.2005.09.011

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The function of the gamma-aminobutyric acid(B) (GABA(B)) receptor, measured as baclofen-stimulated [S-35]GTP gamma S binding, was evaluated in some brain regions of Sardinian alcohol-preferring (sP) and -nonpreferring (sNP) rats. EC50 value of baclofen-stimulated [S-35]GTP gamma S in limbic areas was approximately 125% higher in alcohol-naive sP than sNP rats; voluntarily consumed alcohol reduced the EC50 value to a level similar to that of alcohol-naive sNP rats. These results suggest the presence of a genetically determined lower function of the GABAB receptor in limbic areas of sP than sNP rats; this differential functioning of the GABA(B) receptor may contribute to the opposite preference for alcohol in these rat lines. (c) 2005 Published by Elsevier B.V.

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收藏

页码：67 / 70

页数：4

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