Human FoxP3+ regulatory T cells in systemic autoimmune diseases

被引：338

作者：

Miyara, Makoto ^{[1
,2
,3
]}

Gorochov, Guy ^{[2
,4
]}

Ehrenstein, Michael ^{[5
]}

Musset, Lucile ^{[3
]}

Sakaguchi, Shimon ^{[6
,7
,8
]}

Amoura, Zahir ^{[1
,2
,4
]}

机构：

[1] Hop La Pitie Salpetriere, AP HP, French Natl Reference Ctr SLE & Antiphospholipid, Dept Internal Med, F-75013 Paris, France

[2] Hop La Pitie Salpetriere, AP HP, INSERM, UMR S 945, F-75013 Paris, France

[3] Hop La Pitie Salpetriere, AP HP, Lab Immunochim, F-75013 Paris, France

[4] Univ Paris 06, Paris, France

[5] UCL, Div Med, Ctr Rheumatol, London W1T 4JF, England

[6] Kyoto Univ, Inst Frontier Med Sci, Dept Expt Pathol, Kyoto 6068507, Japan

[7] Japan Sci & Technol Agcy, Kawaguchi, Saitama 3320012, Japan

[8] Osaka Univ, WPI Immunol Frontier Res Ctr, Suita, Osaka 5650871, Japan

来源：

AUTOIMMUNITY REVIEWS | 2011年 / 10卷 / 12期

基金：

日本学术振兴会;

关键词：

FoxP3; Human regulatory T cells; Autoimmune diseases; Systemic Lupus Erythematosus; Rheumatoid Arthritis; Sjogren syndrome; GROWTH-FACTOR-BETA; LUPUS-ERYTHEMATOSUS; RHEUMATOID-ARTHRITIS; PERIPHERAL-BLOOD; SYNOVIAL-FLUID; SELF-TOLERANCE; SLE PATIENTS; CD4(+)CD25(-)FOXP3(+) CELLS; WEGENERS-GRANULOMATOSIS; MEDIATED SUPPRESSION;

D O I：

10.1016/j.autrev.2011.05.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Since the characterization of CD4(+)CD25(+) regulatory T (Treg) cells in mice, significant progress has been made in the definitions of the phenotype and the function of human Treg cells in health and in pathological conditions. Recent advances in the field leading to a better molecular definition of Treg subsets in humans and the description of the dynamics of differentiation of Treg cells should bring new insights in the understanding of human chronic systemic autoimmune diseases. How Treg cells are compromised in these diseases is a challenging issue because the elucidation of the mechanisms leading to such anomaly might lead to promising novel therapeutic approaches. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：744 / 755

页数：12

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