Effects of tetramethylpyrazine phosphate and sodium ferulate alone or in combination on hemodynamics in anesthetized dog

Hemodynamic actions of intravenous (iv) administration of tetramethylpyrazine phosphate (TMPP) and sodium ferulate (SF) alone or in combination were studied in anesthetized dogs. When given alone, TMPP increased left ventricular systolic pressure (LVSP), peak positive first derivative of left ventricular pressure (+LVdp/dt), coronary blood flow (CBF) and heart rate (HR) while decreasing mean aortic pressure (mAoP). SF alone did not produce any significant hemodynamic changes. When the two were administered in combination, SF antagonized dose-dependently the hemodynamic actions of TMPP. Results of this study did not support the efficacy of combined treatment of Ligusticum wallichi and Angelica root, which contain TMPP and SF respectively.