共 31 条
Serum parathyroid hormone, but not menopausal status, is associated with the expression of osteoprotegerin and RANKL mRNA in human bone samples
被引:31
作者:

Seck, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Heidelberg, Dept Gynecol, D-69115 Heidelberg, Germany

Diel, I
论文数: 0 引用数: 0
h-index: 0
机构: Univ Heidelberg, Dept Gynecol, D-69115 Heidelberg, Germany

Bismar, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Heidelberg, Dept Gynecol, D-69115 Heidelberg, Germany

Ziegler, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Heidelberg, Dept Gynecol, D-69115 Heidelberg, Germany

Pfeilschifter, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Heidelberg, Dept Gynecol, D-69115 Heidelberg, Germany
机构:
[1] Univ Heidelberg, Dept Gynecol, D-69115 Heidelberg, Germany
[2] Univ Heidelberg, Dept Internal Med 1, D-69115 Heidelberg, Germany
[3] Ruhr Univ Bochum, Dept Med, D-44789 Bochum, Germany
关键词:
D O I:
10.1530/eje.0.1450199
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Objective: Osteoprotegerin (OPG) and its ligand 'receptor activator of NF-kB ligand' (RANKL) are important regulators of bone metabolism. RANKL, expressed in osteoblasts, activates osteoclast differentiation and osteoclast function by binding the 'receptor activator of NF-kB' (RANK), expressed in ostoclast precursors and mature osteoclasts. The effect is prevented by OPG, a soluble receptor of RANKL. In vitro studies have suggested that estrogen stimulates OPG. whereas parathyroid hormone (PTH) inhibits OPG expression and stimulates the expression of RANKL. Design: In the present study, we examined the relationship between the menopause, serum PTH and the expression of OPG and RANKL in human bone tissue in vivo. Methods: To address this question, we established a 5'-nuclease assay to quantify the mRNA copies of human OPG and RANKL, normalized to the number of copies of beta -actin mRNA in 169 women (mean age: 52.4 +/- 11.6 years), who underwent surgery for early breast cancer. Intact serum PTH was measured by chemoluminescence in 61 women. Results: We found no significant difference in the expression of OPG and RANKL between postmenopausal women and premenopausal women. Also, the ratio of RANKL to OPG was unchanged in relation to the menopausal status. Serum PTH was negatively associated with the expression of OPG (r = -0.33, P = 0.01), but also, surprisingly, with the expression of RANKL (r = -0.28, P = 0.03). Conclusion: We failed to observe the expected changes in the expression of OPG and RANKL in human bone samples at menopause. High in vivo levels of circulating PTH are accompanied by low levels of expression of the two transscripts in human bone tissue.
引用
收藏
页码:199 / 205
页数:7
相关论文
共 31 条
[1]
Osteoclastogenesis inhibitory factor suppresses osteoclast survival by intetfering in the interaction of stromal cells with osteoclast
[J].
Akatsu, T
;
Murakami, T
;
Nishikawa, M
;
Ono, K
;
Shinomiya, N
;
Tsuda, E
;
Mochizuki, S
;
Yamaguchi, K
;
Kinosaki, M
;
Higashio, K
;
Yamamoto, M
;
Motoyoshi, K
;
Nagata, N
.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,
1998, 250 (02)
:229-234

Akatsu, T
论文数: 0 引用数: 0
h-index: 0
机构: Natl Def Med Coll, Dept Internal Med 3, Tokorozawa, Saitama 3598513, Japan

Murakami, T
论文数: 0 引用数: 0
h-index: 0
机构: Natl Def Med Coll, Dept Internal Med 3, Tokorozawa, Saitama 3598513, Japan

Nishikawa, M
论文数: 0 引用数: 0
h-index: 0
机构: Natl Def Med Coll, Dept Internal Med 3, Tokorozawa, Saitama 3598513, Japan

Ono, K
论文数: 0 引用数: 0
h-index: 0
机构: Natl Def Med Coll, Dept Internal Med 3, Tokorozawa, Saitama 3598513, Japan

Shinomiya, N
论文数: 0 引用数: 0
h-index: 0
机构: Natl Def Med Coll, Dept Internal Med 3, Tokorozawa, Saitama 3598513, Japan

Tsuda, E
论文数: 0 引用数: 0
h-index: 0
机构: Natl Def Med Coll, Dept Internal Med 3, Tokorozawa, Saitama 3598513, Japan

Mochizuki, S
论文数: 0 引用数: 0
h-index: 0
机构: Natl Def Med Coll, Dept Internal Med 3, Tokorozawa, Saitama 3598513, Japan

Yamaguchi, K
论文数: 0 引用数: 0
h-index: 0
机构: Natl Def Med Coll, Dept Internal Med 3, Tokorozawa, Saitama 3598513, Japan

Kinosaki, M
论文数: 0 引用数: 0
h-index: 0
机构: Natl Def Med Coll, Dept Internal Med 3, Tokorozawa, Saitama 3598513, Japan

Higashio, K
论文数: 0 引用数: 0
h-index: 0
机构: Natl Def Med Coll, Dept Internal Med 3, Tokorozawa, Saitama 3598513, Japan

Yamamoto, M
论文数: 0 引用数: 0
h-index: 0
机构: Natl Def Med Coll, Dept Internal Med 3, Tokorozawa, Saitama 3598513, Japan

Motoyoshi, K
论文数: 0 引用数: 0
h-index: 0
机构: Natl Def Med Coll, Dept Internal Med 3, Tokorozawa, Saitama 3598513, Japan

Nagata, N
论文数: 0 引用数: 0
h-index: 0
机构: Natl Def Med Coll, Dept Internal Med 3, Tokorozawa, Saitama 3598513, Japan
[2]
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
[J].
Anderson, DM
;
Maraskovsky, E
;
Billingsley, WL
;
Dougall, WC
;
Tometsko, ME
;
Roux, ER
;
Teepe, MC
;
DuBose, RF
;
Cosman, D
;
Galibert, L
.
NATURE,
1997, 390 (6656)
:175-179

Anderson, DM
论文数: 0 引用数: 0
h-index: 0
机构: IMMUNEX RES & DEV CORP, DEPT IMMUNOBIOL, SEATTLE, WA 98101 USA

Maraskovsky, E
论文数: 0 引用数: 0
h-index: 0
机构: IMMUNEX RES & DEV CORP, DEPT IMMUNOBIOL, SEATTLE, WA 98101 USA

Billingsley, WL
论文数: 0 引用数: 0
h-index: 0
机构: IMMUNEX RES & DEV CORP, DEPT IMMUNOBIOL, SEATTLE, WA 98101 USA

Dougall, WC
论文数: 0 引用数: 0
h-index: 0
机构: IMMUNEX RES & DEV CORP, DEPT IMMUNOBIOL, SEATTLE, WA 98101 USA

Tometsko, ME
论文数: 0 引用数: 0
h-index: 0
机构: IMMUNEX RES & DEV CORP, DEPT IMMUNOBIOL, SEATTLE, WA 98101 USA

Roux, ER
论文数: 0 引用数: 0
h-index: 0
机构: IMMUNEX RES & DEV CORP, DEPT IMMUNOBIOL, SEATTLE, WA 98101 USA

Teepe, MC
论文数: 0 引用数: 0
h-index: 0
机构: IMMUNEX RES & DEV CORP, DEPT IMMUNOBIOL, SEATTLE, WA 98101 USA

DuBose, RF
论文数: 0 引用数: 0
h-index: 0
机构: IMMUNEX RES & DEV CORP, DEPT IMMUNOBIOL, SEATTLE, WA 98101 USA

Cosman, D
论文数: 0 引用数: 0
h-index: 0
机构: IMMUNEX RES & DEV CORP, DEPT IMMUNOBIOL, SEATTLE, WA 98101 USA

Galibert, L
论文数: 0 引用数: 0
h-index: 0
机构: IMMUNEX RES & DEV CORP, DEPT IMMUNOBIOL, SEATTLE, WA 98101 USA
[3]
osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
[J].
Bucay, N
;
Sarosi, I
;
Dunstan, CR
;
Morony, S
;
Tarpley, J
;
Capparelli, C
;
Scully, S
;
Tan, HL
;
Xu, WL
;
Lacey, DL
;
Boyle, WJ
;
Simonet, WS
.
GENES & DEVELOPMENT,
1998, 12 (09)
:1260-1268

Bucay, N
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Inc, Dept Mol Genet, Thousand Oaks, CA 91320 USA

Sarosi, I
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Inc, Dept Mol Genet, Thousand Oaks, CA 91320 USA

Dunstan, CR
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Inc, Dept Mol Genet, Thousand Oaks, CA 91320 USA

Morony, S
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Inc, Dept Mol Genet, Thousand Oaks, CA 91320 USA

Tarpley, J
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Inc, Dept Mol Genet, Thousand Oaks, CA 91320 USA

Capparelli, C
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Inc, Dept Mol Genet, Thousand Oaks, CA 91320 USA

Scully, S
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Inc, Dept Mol Genet, Thousand Oaks, CA 91320 USA

Tan, HL
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Inc, Dept Mol Genet, Thousand Oaks, CA 91320 USA

Xu, WL
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Inc, Dept Mol Genet, Thousand Oaks, CA 91320 USA

Lacey, DL
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Inc, Dept Mol Genet, Thousand Oaks, CA 91320 USA

Boyle, WJ
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Inc, Dept Mol Genet, Thousand Oaks, CA 91320 USA

Simonet, WS
论文数: 0 引用数: 0
h-index: 0
机构:
Amgen Inc, Dept Mol Genet, Thousand Oaks, CA 91320 USA Amgen Inc, Dept Mol Genet, Thousand Oaks, CA 91320 USA
[4]
The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts
[J].
Burgess, TL
;
Qian, YX
;
Kaufman, S
;
Ring, BD
;
Van, G
;
Capparelli, C
;
Kelley, M
;
Hsu, HL
;
Boyle, WJ
;
Dunstan, CR
;
Hu, S
;
Lacey, DL
.
JOURNAL OF CELL BIOLOGY,
1999, 145 (03)
:527-538

Burgess, TL
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Inc, Dept Mammalian Cell Mol Biol, Thousand Oaks, CA 91320 USA

Qian, YX
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Inc, Dept Mammalian Cell Mol Biol, Thousand Oaks, CA 91320 USA

Kaufman, S
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Inc, Dept Mammalian Cell Mol Biol, Thousand Oaks, CA 91320 USA

Ring, BD
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Inc, Dept Mammalian Cell Mol Biol, Thousand Oaks, CA 91320 USA

Van, G
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Inc, Dept Mammalian Cell Mol Biol, Thousand Oaks, CA 91320 USA

Capparelli, C
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Inc, Dept Mammalian Cell Mol Biol, Thousand Oaks, CA 91320 USA

Kelley, M
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Inc, Dept Mammalian Cell Mol Biol, Thousand Oaks, CA 91320 USA

Hsu, HL
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Inc, Dept Mammalian Cell Mol Biol, Thousand Oaks, CA 91320 USA

Boyle, WJ
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Inc, Dept Mammalian Cell Mol Biol, Thousand Oaks, CA 91320 USA

Dunstan, CR
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Inc, Dept Mammalian Cell Mol Biol, Thousand Oaks, CA 91320 USA

Hu, S
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Inc, Dept Mammalian Cell Mol Biol, Thousand Oaks, CA 91320 USA

Lacey, DL
论文数: 0 引用数: 0
h-index: 0
机构: Amgen Inc, Dept Mammalian Cell Mol Biol, Thousand Oaks, CA 91320 USA
[5]
SINGLE-STEP METHOD OF RNA ISOLATION BY ACID GUANIDINIUM THIOCYANATE PHENOL CHLOROFORM EXTRACTION
[J].
CHOMCZYNSKI, P
;
SACCHI, N
.
ANALYTICAL BIOCHEMISTRY,
1987, 162 (01)
:156-159

CHOMCZYNSKI, P
论文数: 0 引用数: 0
h-index: 0
机构: NCI,MOLEC ONCOL LAB,FREDERICK,MD 21701

SACCHI, N
论文数: 0 引用数: 0
h-index: 0
机构: NCI,MOLEC ONCOL LAB,FREDERICK,MD 21701
[6]
Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL
[J].
Emery, JG
;
McDonnell, P
;
Burke, MB
;
Deen, KC
;
Lyn, S
;
Silverman, C
;
Dul, E
;
Appelbaum, ER
;
Eichman, C
;
DiPrinzio, R
;
Dodds, RA
;
James, IE
;
Rosenberg, M
;
Lee, JC
;
Young, PR
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
1998, 273 (23)
:14363-14367

Emery, JG
论文数: 0 引用数: 0
h-index: 0
机构: SmithKline Beecham Pharmaceut, Dept Mol Biol, King Of Prussia, PA 19406 USA

McDonnell, P
论文数: 0 引用数: 0
h-index: 0
机构: SmithKline Beecham Pharmaceut, Dept Mol Biol, King Of Prussia, PA 19406 USA

Burke, MB
论文数: 0 引用数: 0
h-index: 0
机构: SmithKline Beecham Pharmaceut, Dept Mol Biol, King Of Prussia, PA 19406 USA

Deen, KC
论文数: 0 引用数: 0
h-index: 0
机构: SmithKline Beecham Pharmaceut, Dept Mol Biol, King Of Prussia, PA 19406 USA

Lyn, S
论文数: 0 引用数: 0
h-index: 0
机构: SmithKline Beecham Pharmaceut, Dept Mol Biol, King Of Prussia, PA 19406 USA

Silverman, C
论文数: 0 引用数: 0
h-index: 0
机构: SmithKline Beecham Pharmaceut, Dept Mol Biol, King Of Prussia, PA 19406 USA

Dul, E
论文数: 0 引用数: 0
h-index: 0
机构: SmithKline Beecham Pharmaceut, Dept Mol Biol, King Of Prussia, PA 19406 USA

Appelbaum, ER
论文数: 0 引用数: 0
h-index: 0
机构: SmithKline Beecham Pharmaceut, Dept Mol Biol, King Of Prussia, PA 19406 USA

Eichman, C
论文数: 0 引用数: 0
h-index: 0
机构: SmithKline Beecham Pharmaceut, Dept Mol Biol, King Of Prussia, PA 19406 USA

DiPrinzio, R
论文数: 0 引用数: 0
h-index: 0
机构: SmithKline Beecham Pharmaceut, Dept Mol Biol, King Of Prussia, PA 19406 USA

Dodds, RA
论文数: 0 引用数: 0
h-index: 0
机构: SmithKline Beecham Pharmaceut, Dept Mol Biol, King Of Prussia, PA 19406 USA

James, IE
论文数: 0 引用数: 0
h-index: 0
机构: SmithKline Beecham Pharmaceut, Dept Mol Biol, King Of Prussia, PA 19406 USA

Rosenberg, M
论文数: 0 引用数: 0
h-index: 0
机构: SmithKline Beecham Pharmaceut, Dept Mol Biol, King Of Prussia, PA 19406 USA

Lee, JC
论文数: 0 引用数: 0
h-index: 0
机构: SmithKline Beecham Pharmaceut, Dept Mol Biol, King Of Prussia, PA 19406 USA

Young, PR
论文数: 0 引用数: 0
h-index: 0
机构: SmithKline Beecham Pharmaceut, Dept Mol Biol, King Of Prussia, PA 19406 USA
[7]
TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts
[J].
Fuller, K
;
Wong, B
;
Fox, S
;
Choi, YW
;
Chambers, TJ
.
JOURNAL OF EXPERIMENTAL MEDICINE,
1998, 188 (05)
:997-1001

Fuller, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ London St Georges Hosp, Sch Med, Dept Expt Pathol, London SW17 0RE, England

Wong, B
论文数: 0 引用数: 0
h-index: 0
机构: Univ London St Georges Hosp, Sch Med, Dept Expt Pathol, London SW17 0RE, England

Fox, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ London St Georges Hosp, Sch Med, Dept Expt Pathol, London SW17 0RE, England

Choi, YW
论文数: 0 引用数: 0
h-index: 0
机构: Univ London St Georges Hosp, Sch Med, Dept Expt Pathol, London SW17 0RE, England

Chambers, TJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ London St Georges Hosp, Sch Med, Dept Expt Pathol, London SW17 0RE, England
[8]
Osteoclastogenesis inhibitory factor (OCIF) directly inhibits bone-resorbing activity of isolated mature osteoclasts
[J].
Hakeda, Y
;
Kobayashi, Y
;
Yamaguchi, K
;
Yasuda, H
;
Tsuda, E
;
Higashio, K
;
Miyata, T
;
Kumegawa, M
.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,
1998, 251 (03)
:796-801

Hakeda, Y
论文数: 0 引用数: 0
h-index: 0
机构:
Meikai Univ, Sch Dent, Dept Oral Anat, Sakado, Saitama 3500283, Japan Meikai Univ, Sch Dent, Dept Oral Anat, Sakado, Saitama 3500283, Japan

Kobayashi, Y
论文数: 0 引用数: 0
h-index: 0
机构: Meikai Univ, Sch Dent, Dept Oral Anat, Sakado, Saitama 3500283, Japan

Yamaguchi, K
论文数: 0 引用数: 0
h-index: 0
机构: Meikai Univ, Sch Dent, Dept Oral Anat, Sakado, Saitama 3500283, Japan

Yasuda, H
论文数: 0 引用数: 0
h-index: 0
机构: Meikai Univ, Sch Dent, Dept Oral Anat, Sakado, Saitama 3500283, Japan

Tsuda, E
论文数: 0 引用数: 0
h-index: 0
机构: Meikai Univ, Sch Dent, Dept Oral Anat, Sakado, Saitama 3500283, Japan

Higashio, K
论文数: 0 引用数: 0
h-index: 0
机构: Meikai Univ, Sch Dent, Dept Oral Anat, Sakado, Saitama 3500283, Japan

Miyata, T
论文数: 0 引用数: 0
h-index: 0
机构: Meikai Univ, Sch Dent, Dept Oral Anat, Sakado, Saitama 3500283, Japan

Kumegawa, M
论文数: 0 引用数: 0
h-index: 0
机构: Meikai Univ, Sch Dent, Dept Oral Anat, Sakado, Saitama 3500283, Japan
[9]
The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption
[J].
Hofbauer, LC
;
Khosla, S
;
Dunstan, CR
;
Lacey, DL
;
Boyle, WJ
;
Riggs, BL
.
JOURNAL OF BONE AND MINERAL RESEARCH,
2000, 15 (01)
:2-12

Hofbauer, LC
论文数: 0 引用数: 0
h-index: 0
机构: Mayo Clin & Mayo Fdn, Endocrine Res Unit, Div Endocrinol & Metab, Rochester, MN 55905 USA

Khosla, S
论文数: 0 引用数: 0
h-index: 0
机构: Mayo Clin & Mayo Fdn, Endocrine Res Unit, Div Endocrinol & Metab, Rochester, MN 55905 USA

Dunstan, CR
论文数: 0 引用数: 0
h-index: 0
机构: Mayo Clin & Mayo Fdn, Endocrine Res Unit, Div Endocrinol & Metab, Rochester, MN 55905 USA

Lacey, DL
论文数: 0 引用数: 0
h-index: 0
机构: Mayo Clin & Mayo Fdn, Endocrine Res Unit, Div Endocrinol & Metab, Rochester, MN 55905 USA

Boyle, WJ
论文数: 0 引用数: 0
h-index: 0
机构: Mayo Clin & Mayo Fdn, Endocrine Res Unit, Div Endocrinol & Metab, Rochester, MN 55905 USA

Riggs, BL
论文数: 0 引用数: 0
h-index: 0
机构: Mayo Clin & Mayo Fdn, Endocrine Res Unit, Div Endocrinol & Metab, Rochester, MN 55905 USA
[10]
Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells
[J].
Hofbauer, LC
;
Khosla, S
;
Dunstan, CR
;
Lacey, DL
;
Spelsberg, TC
;
Riggs, BL
.
ENDOCRINOLOGY,
1999, 140 (09)
:4367-4370

Hofbauer, LC
论文数: 0 引用数: 0
h-index: 0
机构: Mayo Clin & Mayo Fdn, Rochester, MN 55905 USA

Khosla, S
论文数: 0 引用数: 0
h-index: 0
机构: Mayo Clin & Mayo Fdn, Rochester, MN 55905 USA

Dunstan, CR
论文数: 0 引用数: 0
h-index: 0
机构: Mayo Clin & Mayo Fdn, Rochester, MN 55905 USA

Lacey, DL
论文数: 0 引用数: 0
h-index: 0
机构: Mayo Clin & Mayo Fdn, Rochester, MN 55905 USA

Spelsberg, TC
论文数: 0 引用数: 0
h-index: 0
机构: Mayo Clin & Mayo Fdn, Rochester, MN 55905 USA

Riggs, BL
论文数: 0 引用数: 0
h-index: 0
机构: Mayo Clin & Mayo Fdn, Rochester, MN 55905 USA