Vitellogenin regulates hormonal dynamics in the worker caste of a eusocial insect

被引：249

作者：

Guidugli, KR

Nascimento, AM

Amdam, GV

Barchuk, AR

Omholt, S

Simoes, ZLP

Hartfelder, K ^{[1
]}

机构：

[1] Univ Sao Paulo, Dept Biol Celular & Mol & Bioagentes Patogen, Fac Med Ribeirao Preto, Sao Paulo, Brazil

[2] Univ Sao Paulo, Dept Genet, Fac Med Ribeirao Preto, Sao Paulo, Brazil

[3] Univ Sao Paulo, Dept Biol, Fac Filosofia Ciencias & Letras Ribeirao Preto, Sao Paulo, Brazil

[4] Arizona State Univ, Sch Life Sci, Tempe, AZ USA

[5] Norwegian Univ Life Sci, Dept Anim & Aquaculture Sci, As, Norway

来源：

FEBS LETTERS | 2005年 / 579卷 / 22期

基金：

巴西圣保罗研究基金会;

关键词：

juvenile hormone; vitellogenin; ultraspiracle; age polyethism; honey bee;

D O I：

10.1016/j.febslet.2005.07.085

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Functionally sterile honey bee workers synthesize the yolk protein vitellogenin while performing nest tasks. The subsequent shift to foraging is linked to a reduced vitellogenin and an increased juvenile hormone (JH) titer. JH is a principal controller of vitellogenin expression and behavioral development. Yet, we show here that silencing of vitellogenin expression causes a significant increase in JH titer and its putative receptor. Mathematically, the increase corresponds to a dynamic dose-response. This role of vitellogenin in the tuning of the endocrine system is uncommon and may elucidate how an ancestral pathway of fertility regulation has been remodeled into a novel circuit controlling social behavior. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：4961 / 4965

页数：5

共 29 条

[1] Hormonal control of the yolk precursor vitellogenin regulates immune function and longevity in honeybees [J].