Angiotensin I-converting enzyme inhibitory activity and insulin secretion stimulative activity of fermented fish sauce

被引：19

作者：

Ichimura, T

Hu, JN

Aita, DQ

Maruyama, S

机构：

[1] Natl Inst Adv Ind Sci & Technol, Inst Biol Resources & Funct, Tsukuba, Ibaraki 3058566, Japan

[2] Mitsubishi Gas Chem Co Inc, Niigata Res Lab, Niigata 9503112, Japan

来源：

JOURNAL OF BIOSCIENCE AND BIOENGINEERING | 2003年 / 96卷 / 05期

关键词：

fermented fish sauce; dipeptide; antihypertension; insulin secretion;

D O I：

10.1263/jbb.96.496

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Angiotensin I-converting enzyme (ACE) inhibitory peptides, Ala-Pro, Lys-Pro, and Arg-Pro, were isolated from fermented fish sauce. Five other proline-containing dipeptides having weak ACE inhibitory activity were also isolated from the fermented fish sauce. Orally administered Lys-Pro showed a tendency to lower the blood pressure of spontaneously hypertensive rats. As fermented anchovy sauce also stimulated insulin secretion by cultured RINm5F insulinoma cells, the sauce may be useful as a source of biologically active substances.

引用

页码：496 / 499

页数：4

共 9 条

[1]

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