Fat and beyond:: The diverse biology of PPARγ

被引：1674

作者：

Tontonoz, Peter ^{[1
,2
]}

Spiegelman, Bruce M. ^{[3
,4
]}

机构：

[1] Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA

[3] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

来源：

ANNUAL REVIEW OF BIOCHEMISTRY | 2008年 / 77卷

关键词：

adipocyte; inflammation; insulin sensitivity; metabolism; macrophage; nuclear receptor; thiazolidindione;

D O I：

10.1146/annurev.biochem.77.061307.091829

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nuclear receptor PPAR gamma is a ligand-activated transcription factor that plays an important role in the control of gene expression linked to a variety of physiological processes. PPAR gamma was initially characterized as the master regulator for the development of adipose cells. Ligands for PPAR gamma include naturally occurring fatty acids and the thiazolidinedione (TZD) class of antidiabetic drugs. Activation of PPAR gamma improves insulin sensitivity in rodents and humans through a combination of metabolic actions, including partitioning of lipid stores and the regulation of metabolic and inflammatory mediators termed adipokines. PPAR gamma signaling has also been implicated in the control of cell proliferation, atherosclerosis, macrophage function, and immunity. Here, we review recent advances in our understanding of the diverse biological actions of PPAR gamma with an eye toward the expanding therapeutic potential of PPAR gamma agonist drugs.

引用

页码：289 / 312

页数：24

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