Phosphorylcholine: friend or foe of the immune system?

被引：138

作者：

Harnett, W ^{[1
]}

Harnett, MM

机构：

[1] Univ Strathclyde, Dept Immunol, Glasgow G4 0NR, Lanark, Scotland

[2] Univ Glasgow, Dept Immunol, Glasgow G11 6NR, Lanark, Scotland

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 03期

关键词：

D O I：

10.1016/S0167-5699(98)01419-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Phosphorylcholine (PC) is a structural component of a variety of prokaryotic and eukaryotic pathogens. In some cases, PC in infectious agents can benefit the infected host due to its targeting by both the innate and adaptive immune responses. However, as discussed here, PC exhibits a surprising range of immunomodulatory properties that might be to the detriment of the host.

引用

页码：125 / 129

页数：5

共 59 条

[1] The Xid defect imparts susceptibility to experimental murine filariosis - association with a lack of antibody and IL-10 production by B cells in response to phosphorylcholine [J].

Al-Qaoud, KM ;

Fleischer, B ;

Hoerauf, A .

INTERNATIONAL IMMUNOLOGY, 1998, 10 (01) :17-25

[2] SOME ASPECTS OF THE PNEUMOCOCCAL CARRIER STATE [J].

AUSTRIAN, R .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1986, 18 :35-45

[3]

BACH MA, 1983, J IMMUNOL, V131, P365

[4] PHOSPHORYLCHOLINE-CONTAINING ALLERGENS [J].

BALDO, BA ;

KRILIS, S ;

FLETCHER, TC .

NATURWISSENSCHAFTEN, 1979, 66 (12) :623-625

[5] INVITRO PLAQUE-FORMING CELL RESPONSES INDUCED BY STREPTOCOCCUS-PNEUMONIAE IN HUMANS [J].

BECKMANN, E ;

LEVITT, D .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1984, 19 (01) :1-10

[6]

BECKMANN E, 1984, J IMMUNOL, V132, P2174

[7] CYTOKINES IN LEISHMANIASIS - A COMPLEX NETWORK OF STIMULATORY AND INHIBITORY INTERACTIONS [J].

BOGDAN, C ;

GESSNER, A ;

ROLLINGHOFF, M .

IMMUNOBIOLOGY, 1993, 189 (3-4) :356-396

[8] ANTI-PHOSPHOCHOLINE ANTIBODIES FOUND IN NORMAL MOUSE SERUM ARE PROTECTIVE AGAINST INTRAVENOUS INFECTION WITH TYPE-3 STREPTOCOCCUS-PNEUMONIAE [J].

BRILES, DE ;

NAHM, M ;

SCHROER, K ;

DAVIE, J ;

BAKER, P ;

KEARNEY, J ;

BARLETTA, R .

JOURNAL OF EXPERIMENTAL MEDICINE, 1981, 153 (03) :694-705

[9] MOUSE IGG3 ANTIBODIES ARE HIGHLY PROTECTIVE AGAINST INFECTION WITH STREPTOCOCCUS-PNEUMONIAE [J].

BRILES, DE ;

CLAFLIN, JL ;

SCHROER, K ;

FORMAN, C .

NATURE, 1981, 294 (5836) :88-90

[10]

BRILES EB, 1973, J BIOL CHEM, V248, P6394

← 1 2 3 4 5 6 →