Cell transplantation preserves matrix homeostasis: A novel paracrine mechanism

被引：44

作者：

Fedak, PWM

Szmitko, PE

Weisel, RD

Altamentova, SM

Nili, N

Ohno, N

Verma, S

Fazel, S

Strauss, BH

Li, RK

机构：

[1] Univ Toronto, Toronto Gen Hosp, Div Cardiac Surg, Toronto Gen Res Inst, Toronto, ON M5G 2C4, Canada

[2] Univ Toronto, St Michaels Hosp, Div Cardiol, Roy & Ann Foss Res Program,Terrence Donnelly Hear, Toronto, ON M5B 1W8, Canada

来源：

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY | 2005年 / 130卷 / 05期

关键词：

D O I：

10.1016/j.jtcvs.2005.05.055

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: Cell transplantation prevents chamber dilatation, but the underlying molecular mechanisms remain undefined. Structural cardiac remodeling involves matrix degradation from an imbalance of matrix metalloproteinases (MMP) relative to endogenous tissue inhibitors of metalloproteinases (TIMP). We aimed to determine the capacity of cell transplantation to alter extracellular matrix in the failing heart and, in so doing, identify novel paracrine molecular mediators underlying the beneficial effects of cell transplantation on chamber dilatation.

引用

收藏

页码：1430 / 1439

页数：10

相关论文

共 29 条

[1] Local overexpression of TIMP-1 prevents aortic aneurysm degeneration and rupture in a rat model [J].

Allaire, E ;

Forough, R ;

Clowes, W ;

Starcher, B ;

Clowes, AW .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (07) :1413-1420

[2] Paracrine effect of vascular smooth muscle cells in the prevention of aortic aneurysm formation [J].

Allaire, E ;

Muscatelli-Groux, B ;

Mandet, C ;

Guinault, AM ;

Bruneval, P ;

Desgranges, P ;

Clowes, A ;

Méllière, D ;

Becquemin, JP .

JOURNAL OF VASCULAR SURGERY, 2002, 36 (05) :1018-1026

[3] Changes in extracellular collagen matrix alter myocardial systolic performance [J].

Baicu, CF ;

Stroud, JD ;

Livesay, VA ;

Hapke, E ;

Holder, J ;

Spinale, FG ;

Zile, MR .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2003, 284 (01) :H122-H132

[4] Characterization of differential gene expression in quiescent and invasive human arterial smooth muscle cells [J].

Blindt, R ;

Vogt, F ;

Lamby, D ;

Zeiffer, U ;

Krott, N ;

Hilger-Eversheim, K ;

Hanrath, P ;

vom Dahl, J ;

Bosserhoff, AK .

JOURNAL OF VASCULAR RESEARCH, 2002, 39 (04) :340-352

[5] TNF-α and myocardial matrix metalloproteinases in heart failure:: relationship to LV remodeling [J].

Bradham, WS ;

Moe, G ;

Wendt, KA ;

Scott, AA ;

Konig, A ;

Romanova, M ;

Naik, G ;

Spinale, FG .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2002, 282 (04) :H1288-H1295

[6] Adenovirus-mediated gene transfer of the human tissue inhibitor of metalloproteinase-2 blocks vascular smooth muscle cell invasiveness in vitro and modulates neointimal development in vivo [J].

Cheng, L ;

Mantile, G ;

Pauly, R ;

Nater, C ;

Felici, A ;

Monticone, R ;

Bilato, C ;

Gluzband, YA ;

Crow, MT ;

Stetler-Stevenson, W ;

Capogrossi, MC .

CIRCULATION, 1998, 98 (20) :2195-2201

[7] Cardiac remodeling-concepts and clinical implications: A consensus paper from an international forum on cardiac remodeling [J].

Cohn, JN ;

Ferrari, R ;

Sharpe, N .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2000, 35 (03) :569-582

[8] Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction [J].

Ducharme, A ;

Frantz, S ;

Aikawa, M ;

Rabkin, E ;

Lindsey, M ;

Rohde, LE ;

Schoen, FJ ;

Kelly, RA ;

Werb, Z ;

Libby, P ;

Lee, RT .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 106 (01) :55-62

[9] Cardiac remodeling and failure - From molecules to man (Part 1) [J].

Fedak, PWM ;

Venna, S ;

Weisel, RD ;

Li, RK .

CARDIOVASCULAR PATHOLOGY, 2005, 14 (01) :1-11

[10] TIMP-3 deficiency leads to dilated cardiomyopathy [J].

Fedak, PWM ;

Smookler, DS ;

Kassiri, Z ;

Ohno, N ;

Leco, KJ ;

Verma, S ;

Mickle, DAG ;

Watson, KL ;

Hojilla, CV ;

Cruz, W ;

Weisel, RD ;

Li, RK ;

Khokha, R .

CIRCULATION, 2004, 110 (16) :2401-2409