Chitosan-based drug delivery systems

被引：843

作者：

Bernkop-Schnuerch, Andreas ^{[1
]}

Duennhaupt, Sarah ^{[1
]}

机构：

[1] Univ Innsbruck, Dept Pharmaceut Technol, A-6020 Innsbruck, Austria

来源：

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2012年 / 81卷 / 03期

关键词：

Chitosan; Drug delivery; Mucoadhesion; Permeation enhancement; Controlled release; IN-VITRO EVALUATION; N-TRIMETHYL CHITOSAN; POORLY ABSORBABLE DRUGS; ABSORPTION ENHANCERS; MOLECULAR-WEIGHT; ORAL DELIVERY; CHITOSAN/CYCLODEXTRIN NANOPARTICLES; MUCOADHESIVE MICROSPHERES; INTESTINAL-ABSORPTION; THIOLATED CHITOSANS;

D O I：

10.1016/j.ejpb.2012.04.007

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Within the past 20 years, a considerable amount of work has been published on chitosan and its potential use in drug delivery systems. In contrast to all other polysaccharides having a monograph in a pharmacopeia, chitosan has a cationic character because of its primary amino groups. These primary amino groups are responsible for properties such as controlled drug release, mucoadhesion, in situ gellation, transfection, permeation enhancement, and efflux pump inhibitory properties. Due to chemical modifications, most of these properties can even be further improved. Within this review, an overview on the advantages of chitosan for various types of drug delivery systems is provided. (C) 2012 Published by Elsevier B.V.

引用

页码：463 / 469

页数：7

共 77 条

[1]

Synthesis of iron-crosslinked chitosan succinate and iron-crosslinked hydroxamated chitosan succinate and their in vitro evaluation as potential matrix materials for oral theophylline sustained-release beads [J].

Aiedeh, K ;

Taha, MO .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2001, 13 (02) :159-168

[2]

Evaluation of oral mucoadhesive microspheres in man on the basis of the pharmacokinetics of furosemide and riboflavin, compounds with limited gastrointestinal absorption sites [J].

Akiyama, Y ;

Nagahara, N ;

Nara, E ;

Kitano, M ;

Iwasa, S ;

Yamamoto, I ;

Azuma, J ;

Ogawa, Y .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1998, 50 (02) :159-166

[3]

Carbohydrate biopolymers enhance antibody responses to mucosally delivered vaccine antigens [J].

Bacon, A ;

Makin, J ;

Sizer, PJ ;

Jabbal-Gill, I ;

Hinchcliffe, M ;

Illum, L ;

Chatfield, S ;

Roberts, M .

INFECTION AND IMMUNITY, 2000, 68 (10) :5764-5770

[4]

Adjuvanted, antigen loaded N-trimethyl chitosan nanoparticles for nasal and intradermal vaccination: Adjuvant- and site-dependent immunogenicity in mice [J].

Bal, Suzanne M. ;

Slutter, Bram ;

Verheul, Rolf ;

Bouwstra, Joke A. ;

Jiskoot, Wim .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2012, 45 (04) :475-481

[5]

Development of a mucoadhesive nanoparticulate drug delivery system for a targeted drug release in the bladder [J].

Barthelmes, Jan ;

Perera, Glen ;

Hombach, Juliane ;

Duennhaupt, Sarah ;

Bernkop-Schnuerch, Andreas .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2011, 416 (01) :339-345

[6]

Development of a sustained release dosage form for α-lipoic acid.: II.: Evaluation in human volunteers [J].

Bernkop-Schnürch, A ;

Reich-Rohrwig, E ;

Marschütz, M ;

Schuhbauer, H ;

Kratzel, M .

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2004, 30 (01) :35-42

[7]

Thiolated polymers-thiomers:: synthesis and in vitro evaluation of chitosan-2-iminothiolane conjugates [J].

Bernkop-Schnürch, A ;

Hornof, M ;

Zoidl, T .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2003, 260 (02) :229-237

[8]

Effect of drying methods on swelling, erosion and drug release from chitosan-naproxen sodium complexes [J].

Bhise, Kiran S. ;

Dhumal, Ravindra S. ;

Paradkar, Anant R. ;

Kadam, Shivajirao S. .

AAPS PHARMSCITECH, 2008, 9 (01) :1-12

[9]

Immune response by nasal delivery of hepatitis B surface antigen and codelivery of a CpG ODN in alginate coated chitosan nanoparticles [J].

Borges, Olga ;

Cordeiro-da-Silva, Anabela ;

Tavares, Joana ;

Santarem, Nuno ;

de Sousa, Adriano ;

Borchard, Gerrit ;

Junginger, Hans E. .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2008, 69 (02) :405-416

[10]

Evaluation of cationic polymer-coated nanocapsules as ocular drug carriers [J].

Calvo, P ;

VilaJato, JL ;

Alonso, MJ .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1997, 153 (01) :41-50

← 1 2 3 4 5 6 7 8 →