PDE4 inhibitors 1998

被引：19

作者：

Norman, P

机构：

[1] 18 Pink Lane, Burnham

来源：

EXPERT OPINION ON THERAPEUTIC PATENTS | 1998年 / 8卷 / 07期

关键词：

asthma; PDE4; inhibitor; rheumatoid arthritis;

D O I：

10.1517/13543776.8.7.771

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The search for novel phosphodiesterase Type 4 (PDE4) inhibitors is currently one of the most active fields within the pharmaceutical industry. Recent progress in the clinical development of PDE4 inhibitors is reviewed. Particular emphasis is placed on those patents published within the past two years, highlighting the novel structural classes of PDE4 inhibitors reported.

引用

页码：771 / 784

页数：14

共 45 条

[1]

Barnette MS, 1998, J PHARMACOL EXP THER, V284, P420

[2] IS PHOSPHODIESTERASE INHIBITION A NEW MECHANISM OF ANTIDEPRESSANT ACTION - A DOUBLE-BLIND DOUBLE-DUMMY STUDY BETWEEN ROLIPRAM AND DESIPRAMINE IN HOSPITALIZED MAJOR AND OR ENDOGENOUS DEPRESSIVES [J].

BOBON, D ;

BREULET, M ;

GERARDVANDENHOVE, MA ;

GUIOTGOFFIOUL, F ;

PLOMTEUX, G ;

SASTREYHERNANDEZ, M ;

SCHRATZER, M ;

TROISFONTAINES, B ;

VONFRENCKELL, R ;

WACHTEL, H .

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 1988, 238 (01) :2-6

[3]

Cavalla D, 1997, DRUG NEWS PERSPECT, V10, P470

[4] Biarylcarboxamide inhibitors of phosphodiesterase IV and tumor necrosis factor-alpha [J].

Chambers, RJ ;

Marfat, A ;

Cheng, JB ;

Cohan, VL ;

Damon, DB ;

Duplantier, AJ ;

Hibbs, TA ;

Jenkinson, TH ;

Johnson, KL ;

Kraus, KG ;

Pettipher, ER ;

Salter, ED ;

Shirley, JT ;

Umland, JP .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (06) :739-744

[5]

Cheng JB, 1997, J PHARMACOL EXP THER, V280, P621

[6]

Chikanza I. C., 1996, Arthritis and Rheumatism, V39, pS282

[7] 1,4-cyclohexanecarboxylates: Potent and selective inhibitors of phosphodiesterase 4 for the treatment of asthma [J].

Christensen, SB ;

Guider, A ;

Forster, CJ ;

Gleason, JG ;

Bender, PE ;

Karpinski, JM ;

DeWolf, WE ;

Barnette, MS ;

Underwood, DC ;

Griswold, DE ;

Cieslinski, LB ;

Burman, M ;

Bochnowicz, S ;

Osborn, RR ;

Manning, CD ;

Grous, M ;

Hillegas, LM ;

Bartus, JO ;

Ryan, MD ;

Eggleston, DS ;

Haltiwanger, RC ;

Torphy, TJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (06) :821-835

[8]

CHRISTENSEN SB, 1996, PHOSPHODIESTERASE IH, P41

[9]

Cohan VL, 1996, J PHARMACOL EXP THER, V278, P1356

[10] Biarylcarboxylic acids and -amides: Inhibition of phosphodiesterase type IV versus [H-3]rolipram binding activity and their relationship to emetic behavior in the ferret [J].

Duplantier, AJ ;

Biggers, MS ;

Chambers, RJ ;

Cheng, JB ;

Cooper, K ;

Damon, DB ;

Eggler, JF ;

Kraus, KG ;

Marfat, A ;

Masamune, H ;

Pillar, JS ;

Shirley, JT ;

Umland, JP ;

Watson, JW .

JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (01) :120-125

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