Gastric cell apoptosis and H-pylori:: has the main function of VacA finally been identified?

被引：51

作者：

Boquet, P

Ricci, V

Galmiche, A

Gauthier, NC

机构：

[1] Fac Med Nice, INSERM, U452, Nice, France

[2] Univ Pavia, Dept Expt Med, Human Physiol Sect, I-27100 Pavia, Italy

[3] Max Planck Inst Infect Biol, Dept Cellular Microbiol, Berlin, Germany

来源：

TRENDS IN MICROBIOLOGY | 2003年 / 11卷 / 09期

关键词：

D O I：

10.1016/S0966-842X(03)00211-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The vacuolating cytotoxin VacA is one of the most important virulence factors of Helicobacter pylori, a bacterium causing severe gastric diseases such as ulcers and cancer. VacA forms large cytoplasmic vacuoles in cultured cells, although its effects on host cells in vivo remain to be elucidated. Three independent groups have reported that VacA induces epithelial cell apoptosis. In particular, a recent study has demonstrated unambiguously the role of VacA in inducing epithelial gastric cell apoptosis.

引用

页码：410 / 413

页数：4

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