Reflex conditioning: a new strategy for improving motor function after spinal cord injury

被引：12

作者：

Chen, Xiang Yang ^{[1
,2
]}

Chen, Yi ^{[1
]}

Wang, Yu ^{[1
]}

Thompson, Aiko ^{[3
]}

Carp, Jonathan S. ^{[1
,2
]}

Segal, Richard L. ^{[4
]}

Wolpaw, Jonathan R. ^{[1
,2
]}

机构：

[1] New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA

[2] SUNY Albany, Albany, NY 12201 USA

[3] Helen Hayes Hosp, W Haverstraw, NY USA

[4] Univ N Carolina, Chapel Hill, NC USA

来源：

DISCOVERIES IN SPINAL CORD INJURY RESEARCH: FROM BENCH TO BEDSIDE | 2010年 / 1198卷 / S1期

基金：

美国国家卫生研究院;

关键词：

spinal cord injury; reflex conditioning; plasticity; H-reflex; learning and memory; locomotion; rehabilitation; PRIMATE H-REFLEX; MOTONEURON PLASTICITY; STRETCH REFLEXES; SOLEUS MUSCLE; RATS; SKILL; DECEREBRATE; CEREBELLUM; TERMINALS; ABLATION;

D O I：

10.1111/j.1749-6632.2010.05565.x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Spinal reflex conditioning changes reflex size, induces spinal cord plasticity, and modifies locomotion. Appropriate reflex conditioning can improve walking in rats after spinal cord injury (SCI). Reflex conditioning offers a new therapeutic strategy for restoring function in people with SCI. This approach can address the specific deficits of individuals with SCI by targeting specific reflex pathways for increased or decreased responsiveness. In addition, once clinically significant regeneration can be achieved, reflex conditioning could provide a means of reeducating the newly (and probably imperfectly) reconnected spinal cord.

引用

页码：E12 / E21

页数：10

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