Controlling antimicrobial resistance in hospitals: Infection control and use of antibiotics

被引:164
作者
Weinstein, RA
机构
[1] Cook Cty Hosp, Div Infect Dis, Chicago, IL 60612 USA
[2] Rush Med Coll, Chicago, IL 60612 USA
关键词
D O I
10.3201/eid0702.010206
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Antimicrobial-drug resistance in hospitals is driven by failures of hospital hygiene, selective pressures created by overuse of antibiotics, and mobile genetic elements that can encode bacterial resistance mechanisms. Attention to hand hygiene is constrained by the time it takes to wash hands and by the adverse effects of repeated handwashing on the skin. Alcohol-based hand rubs can overcome the time problem and actually improve skin condition. Universal glove use could close gaps left by incomplete adherence to hand hygiene. Various interventions have been described to improve antibiotic use. The most effective have been programs restricting use of antibiotics and computer-based order forms for health providers.
引用
收藏
页码:188 / 192
页数:5
相关论文
共 39 条
[1]   Vancomycin-resistant enterococci in intensive-care hospital settings: Transmission dynamics, persistence, and the impact of infection control programs [J].
Austin, DJ ;
Bonten, MJM ;
Weinstein, RA ;
Slaughter, S ;
Anderson, RM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (12) :6908-6913
[2]  
Badri SM, 1998, 36 ANN M INF DIS SOC
[3]   Skin colonization with vancomycin-resistant enterococci among hospitalized patients with bacteremia [J].
Beezhold, DW ;
Slaughter, S ;
Hayden, MK ;
Matushek, M ;
Nathan, C ;
Trenholme, GM ;
Weinstein, RA .
CLINICAL INFECTIOUS DISEASES, 1997, 24 (04) :704-706
[4]   Evaluating treatment protocols to prevent antibiotic resistance [J].
Bonhoeffer, S ;
Lipsitch, M ;
Levin, BR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (22) :12106-12111
[5]   Epidemiology of colonisation of patients and environment with vancomycin-resistant enterococci [J].
Bonten, MJM ;
Hayden, MK ;
Nathan, C ;
vanVoorhis, J ;
Matushek, M ;
Slaughter, S ;
Rice, T ;
Weinstein, RA .
LANCET, 1996, 348 (9042) :1615-1619
[6]   The role of "colonization pressure" in the spread of vancomycin-resistant enterococci - An important infection control variable [J].
Bonten, MJM ;
Slaughter, S ;
Ambergen, AW ;
Hayden, MK ;
van Voorhis, J ;
Nathan, C ;
Weinstein, RA .
ARCHIVES OF INTERNAL MEDICINE, 1998, 158 (10) :1127-1132
[7]  
BOYCE J, 2001, IN PRESS EMERG INFEC, V7
[8]   OUTBREAK OF MULTIDRUG-RESISTANT ENTEROCOCCUS-FAECIUM WITH TRANSFERABLE VANB CLASS VANCOMYCIN RESISTANCE [J].
BOYCE, JM ;
OPAL, SM ;
CHOW, JW ;
ZERVOS, MJ ;
POTTERBYNOE, G ;
SHERMAN, CB ;
ROMULO, RLC ;
FORTNA, S ;
MEDEIROS, AA .
JOURNAL OF CLINICAL MICROBIOLOGY, 1994, 32 (05) :1148-1153
[9]  
BOYCE JM, 1999, P 9 ANN SOC HEALTHC
[10]   IMPROVED ANTIBIOTIC USAGE FOLLOWING INTRODUCTION OF A NOVEL PRESCRIPTION SYSTEM [J].
DURBIN, WA ;
LAPIDAS, B ;
GOLDMANN, DA .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1981, 246 (16) :1796-1800