New types of conserved sequence domains in DNA-binding regions of homing endonucleases

被引：35

作者：

Sitbon, E ^{[1
]}

Pietrokovski, S ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2003年 / 28卷 / 09期

关键词：

D O I：

10.1016/S0968-0004(03)00170-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have identified four new types of short conserved sequence domains in homing endonucleases and related proteins. These domains are modular, appearing in various combinations. One domain includes a motif known by structure as a novel sequence-specific DNA-binding helix. Sequence similarity shows two other domains to be new types of helix-turn-helix DNA-binding domains. We term the new domains nuclease-associated modular DNA-binding domains (NUMODs).

引用

页码：473 / 477

页数：5

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