Antifibrotic effect of the herbal medicine Saiko-keishi-to (TJ-10) on chronic pancreatitis in the WBN/Kob rat

被引：23

作者：

Su, SB ^{[1
]}

Motoo, Y ^{[1
]}

Xie, MJ ^{[1
]}

Taga, H ^{[1
]}

Sawabu, N ^{[1
]}

机构：

[1] Kanazawa Univ, Canc Res Inst, Dept Internal Med & Med Oncol, Kanazawa, Ishikawa 9218044, Japan

来源：

PANCREAS | 2001年 / 22卷 / 01期

关键词：

Saiko-keishi-to; pancreatic fibrosis; chronic pancreatitis; fibrosis-related factors; WBN/Kob rat;

D O I：

10.1097/00006676-200101000-00002

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Chronic pancreatitis is characterized by fibrosis. We reported an anti-inflammatory effect of the herbal medicine Saiko-keishi-to (TJ-10) on chronic pancreatitis. This study aimed to elucidate the antifibrotic effect of TJ-10. Four-week-old male WBN/Kob rats were fed a special pellet diet (MB-3) with or without TJ-10 (80 mg/100 g body weight) for 20 weeks. Pancreata were histopathologically examined at every 4 weeks, and the expression of fibrosis-related factors such as transforming growth factor beta (1) (TGF-beta (1)), fibronectin (FN), alpha -smooth muscle actin (alpha -SMA), and type III collagen was analyzed. In untreated WBN/Kob rats, chronic pancreatitis developed at 12 weeks and progressed with marked fibrosis at 16 weeks, and the expression of TGF-beta (1) and FN peaked at 12 weeks. However, in the TJ-10-treated rats, the rate of pancreatic fibrosis and the expression of TGF-beta (1), FN, alpha -SMA, and type III collagen at 12 and 16 weeks decreased significantly compared to those in the untreated rats. These results suggest that TJ-10 inhibits the pancreatic fibrosis by the suppression of TGF-beta (1) expression.

引用

页码：8 / 17

页数：10

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