Differential control of peripheral circadian rhythms by suprachiasmatic-dependent neural signals

被引:193
作者
Guo, HN
Brewer, JM
Champhekar, A
Harris, RBS
Bittman, EL [1 ]
机构
[1] Univ Massachusetts, Dept Biol, Morrill Sci Ctr 221, Amherst, MA 01003 USA
[2] Univ Massachusetts, Neurosci & Behav Program, Amherst, MA 01003 USA
[3] Univ Georgia, Dept Foods & Nutr, Athens, GA 30602 USA
关键词
suprachiasmatic; parabiosis; entrainment;
D O I
10.1073/pnas.0409734102
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Although dependent on the integrity of a central pacemaker in the suprachiasmatic nucleus of the hypothalamus (SCN), endogenous daily (circadian) rhythms are expressed in a wide variety of peripheral organs. The pathways by which the pacemaker controls the periphery are unclear. Here, we used parabiosis between intact and SCN-lesioned mice to show that nonneural (behavioral or bloodborne) signals are adequate to maintain circadian rhythms of clock gene expression in liver and kidney, but not in heart, spleen, or skeletal muscle. These results indicate that the SCN regulates expression of circadian oscillations in different peripheral organs by diverse pathways.
引用
收藏
页码:3111 / 3116
页数:6
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