Catalytic asymmetric addition of β-ketoesters to various Imines by using chiral palladium complexes

被引：166

作者：

Hamashima, Y ^{[1
]}

Sasamoto, N ^{[1
]}

Hotta, D ^{[1
]}

Somei, H ^{[1
]}

Umebayashi, N ^{[1
]}

Sodeoka, M ^{[1
]}

机构：

[1] Tohoku Univ, IMRAM, Sendai, Miyagi 9808577, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 10期

关键词：

asymmetric catalysis; enolates; Mannich reaction; palladium; Schiff bases;

D O I：

10.1002/anie.200462202

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly enantioselective Mannich-type reaction of β-ketoesters was developed using a catalytic amount of the Pd-aqua complexes 1 (see scheme; PG = protecting group). A variety of imines derived from glyoxylate, as well as simple aromatic and α,β-unsaturated aldehydes were successfully used. The corresponding Mannich adducts were obtained in high yield with excellent enantioselectivity. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1525 / 1529

页数：5

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