Cigarette smoke condensate extracts augment collagen-induced arthritis in mice

被引：23

作者：

Chujo, Satomi ^{[1
]}

Okamoto, Shosuke ^{[1
]}

Sunahara, Ryohei ^{[1
]}

Adachi, Miki ^{[1
]}

Yamada, Kyohei ^{[1
]}

Hayashi, Hidetoshi ^{[2
]}

Takii, Takemasa ^{[1
]}

Hayakawa, Kazuichi ^{[3
]}

Onozaki, Kikuo ^{[1
]}

机构：

[1] Nagoya City Univ, Grad Sch Pharmaceut Sci, Dept Mol Hlth Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan

[2] Nagoya City Univ, Grad Sch Pharmaceut Sci, Dept Drug Metab & Disposit, Mizuho Ku, Nagoya, Aichi 4678603, Japan

[3] Kanazawa Univ, Inst Med Pharmaceut & Hlth Sci, Kanazawa, Ishikawa 9201192, Japan

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2010年 / 10卷 / 10期

基金：

日本学术振兴会;

关键词：

Arthritis; Rheumatoid; Cigarette; Smoking; CIA; Aryl hydrocarbon; POLYCYCLIC AROMATIC-HYDROCARBONS; RHEUMATOID-ARTHRITIS; SYNOVIOCYTE LINE; RECEPTOR; EXPRESSION; GENE; INTERLEUKIN-1;

D O I：

10.1016/j.intimp.2010.06.026

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Although cigarette smoking is a solid environmental risk factor for rheumatoid arthritis (RA) as revealed by epidemiological studies, the scientific basis has not been provided. Proinflammatory cytokines produced by synoviocytes are implicated in the pathogenesis of RA. As cigarette smoke condensate (CSC) is able to upregulate the production of proinflammatory cytokines from human fibroblast-like synoviocytes, we studied the effect of CSC on induction of arthritis in the mouse model of collagen type II-induced arthritis (CIA). When mainstream CSC or sidestream CSC was administered into DBA/1J mice at the time of immunization with collagen and complete Freund adjuvant, CSC dose-dependently augmented the induction and clinical development of arthritis at both young and older mice. Peritoneal injected mainstream CSC one day before immunization also exhibited the augmenting effect, suggesting the systemic effect of CSC. These results support the etiological role of cigarette smoking in RA. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：1194 / 1199

页数：6

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