Genome-wide linkage analysis of pulse pressure in Mexican Americans

被引:43
作者
Atwood, LD
Samollow, PB
Hixson, JE
Stern, MP
MacCluer, JW
机构
[1] Univ Minnesota, Div Epidemiol, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Inst Human Genet, Minneapolis, MN 55455 USA
[3] SW Fdn Biomed Res, Dept Genet, San Antonio, TX USA
[4] Univ Texas, Hlth Sci Ctr, Ctr Human Genet, Houston, TX USA
[5] Univ Texas, Hlth Sci Ctr, Dept Med, San Antonio, TX 78284 USA
关键词
population; genetics; blood pressure; hypertension; genetic; cardiovascular diseases;
D O I
10.1161/01.HYP.37.2.425
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Pulse pressure, a measure of aortic stiffness, is a strong predictor of cardiovascular mortality. To locate genes that affect pulse pressure, we performed genetic analysis on randomly ascertained families in the San Antonio Family Heart Study. Pulse pressure was defined as the difference between systolic and diastolic blood pressures. Likelihood methods were used to construct a model that had both single-locus and polygenic components for 46 families (1308 individuals). The single-locus component included sex-specific and genotype-specific effects of both age and body mass index. Using this model, we then performed 2-point Linkage analysis in 10 families (440 individuals) that were among the largest of the 46 families and that had been genotyped for 399 polymorphic markers. The model that contained only the polygenic component and simple effects of the covariates showed pulse pressure heritability of 0.21. When the single-locus component was added, the sex-specific and genotype-specific effects of age and body mass index were highly significant (P<0.002). The full model accounted for 73% of the total variation of pulse pressure. Linkage analysis using this model with each marker revealed 4 markers with lod scores >1.9, which is the Lander-Kruglyak suggestive linkage standard. D21S1440 had a lod score of 2.78 with a recombination fraction (theta) of 0.02, D7S1799 had a lod score of 2.04 (theta =0.01), D8S1100 had a lod score of 1.98 (theta =0.08), and D18S844 had a lod score of 1.95 (theta =0.11). These results are highly correlated with results involving systolic blood pressure, indicating that pulse pressure may not be genetically distinct from systolic blood pressure.
引用
收藏
页码:425 / 428
页数:4
相关论文
共 25 条
  • [1] ATWOOD L, IN PRESS GENET EPIDE
  • [2] Linkage of essential hypertension to the angiotensinogen locus in Mexican Americans
    Atwood, LD
    Kammerer, CM
    Samollow, PB
    Hixson, JE
    Shade, RE
    MacCluer, JW
    [J]. HYPERTENSION, 1997, 30 (03) : 326 - 330
  • [3] Atwood LD, 1997, GENET EPIDEMIOL, V14, P755, DOI 10.1002/(SICI)1098-2272(1997)14:6<755::AID-GEPI32>3.0.CO
  • [4] 2-N
  • [5] Pulse pressure and cardiovascular mortality in normotensive and hypertensive subjects
    Benetos, A
    Rudnichi, A
    Safar, M
    Guize, L
    [J]. HYPERTENSION, 1998, 32 (03) : 560 - 564
  • [6] A metric map of humans: 23,500 loci in 850 bands
    Collins, A
    Frezal, J
    Teague, J
    Morton, NE
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (25) : 14771 - 14775
  • [7] Aldosterone excretion rate and blood pressure in essential hypertension are related to polymorphic differences in the aldosterone synthase gene CYP11B2
    Davies, E
    Holloway, CD
    Ingram, MC
    Inglis, GC
    Friel, EC
    Morrison, C
    Anderson, NH
    Fraser, R
    Connell, JMC
    [J]. HYPERTENSION, 1999, 33 (02) : 703 - 707
  • [8] Autosomal dominant orthostatic hypotensive disorder maps to chromosome 18q
    DeStefano, AL
    Baldwin, CT
    Burzstyn, M
    Gavras, I
    Handy, DE
    Joost, O
    Martel, T
    Nicolaou, M
    Schwartz, F
    Streeten, DHP
    Farrer, LA
    Gavras, H
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 1998, 63 (05) : 1425 - 1430
  • [9] Dyke B., 1996, PEDSYS: A Pedigree Database Management System Users Manual
  • [10] Is pulse pressure useful in predicting risk for coronary heart disease? The Framingham Heart Study
    Franklin, SS
    Khan, SA
    Wong, ND
    Larson, MG
    Levy, D
    [J]. CIRCULATION, 1999, 100 (04) : 354 - 360