Oxymatrine, the Main Alkaloid Component of Sophora Roots, Protects Heart against Arrhythmias in Rats

被引：50

作者：

Gan Runtao ^{[1
]}

Dong Guo ^{[1
]}

Yu Jiangbo ^{[1
]}

Wang Xu ^{[1
]}

Yang Shusen ^{[1
]}

机构：

[1] Harbin Med Univ, Affiliated Hosp 1, Dept Cardiol, Harbin 150001, Peoples R China

来源：

PLANTA MEDICA | 2011年 / 77卷 / 03期

关键词：

oxymatrine; arrhythmias; sodium channel; calcium channel; ISCHEMIA; SODIUM; CALCIUM; APOPTOSIS;

D O I：

10.1055/s-0030-1250256

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Oxymatrine is one of the main alkaloid components extracted from Sophora roots and has been shown to play various protective roles in the cardiovascular system. The present study was designed to study the protective effect of oxymatrine on arrhythmias and their ionic channel mechanism. Rat arrhythmic models were established by aconitine injection and coronary artery ligation. Rat cardiomyocytes were acutely isolated, and the whole-cell patch clamp technique was employed to investigate the effects of oxymatrine on sodium channels. Pretreatment with oxymatrine markedly increased the dose of aconitine required to induce arrhythmias in rats. Additionally, oxymatrine significantly delayed the initial time and shortened the duration time of rat arrhythmias induced by coronary artery ligation. Cardiac mortality rate in coronary artery ligation-induced arrhythmias was also effectively decreased by oxymatrine in rats. The electrophysiological study showed that oxymatrine could significantly inhibit sodium and calcium currents in isolated rat cardiomyocytes in a concentration-dependent manner. In summary, oxymatrine plays a remarkably preventive role in rat arrhythmias through the inhibition of sodium and calcium currents.

引用

页码：226 / 230

页数：5

共 28 条

[1]

Effects of sodium-calcium exchange inhibitors, KB-R7943 and SEA0400, on aconitine-induced arrhythmias in guinea pigs in vivo, in vitro, and in computer simulation studies [J].