Manipulating IL-10 signalling blockade for better immunotherapy

被引：75

作者：

Ni, Guoying ^{[1
]}

Wang, Tianfang ^{[4
]}

Walton, Shelley ^{[2
]}

Zhu, Bin ^{[3
]}

Chen, Shu ^{[3
]}

Wu, Xiaolian ^{[3
]}

Wang, Yuejian ^{[3
]}

Wei, Ming Q. ^{[1
]}

Liu, Xiaosong ^{[2
,3
]}

机构：

[1] Griffith Univ, Griffith Hlth Inst, Sch Med Sci, Gold Coast, Qld 4222, Australia

[2] Univ Sunshine Coast, Inflammat & Healing Res Cluster, Sippy Downs, Qld 4556, Australia

[3] Foshan First Peoples Hosp, Canc Res Inst, Foshan 528000, Guangdong, Peoples R China

[4] Univ Sunshine Coast, Genecol Res Ctr, Sippy Downs, Qld 4556, Australia

来源：

CELLULAR IMMUNOLOGY | 2015年 / 293卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Interleukin; 10; Immunotherapy; Vaccine; T-CELL EXHAUSTION; CHRONIC VIRAL-INFECTION; PERSISTENT LCMV INFECTION; INHIBITS TUMOR-METASTASIS; HEPATITIS-C VIRUS; THERAPEUTIC VACCINE; IFN-GAMMA; INTERLEUKIN-10; RECEPTOR; IMMUNE-RESPONSE; PAPILLOMAVIRUS INFECTION;

D O I：

10.1016/j.cellimm.2014.12.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Interleukin 10 is a cytokine with the ability to reduce or terminate inflammation. Chronic viral infection, such as infection of chronic hepatitis B, hepatitis C and HIV, has increased levels of interleukin 10 in peripheral blood. Serum IL-10 levels are also high in certain cancers. Blocking IL-10 signalling at the time of immunisation clears chronic viral infection and prevents tumour growth in animal models. We review recent advances in this area, with the emphasis on potential use of this novel strategy to treat chronic viral infection and cancer in human. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：126 / 129

页数：4

共 74 条

[1]

Human papillomaviruses and associated malignancies [J].

Alani, RM ;

Münger, K .

JOURNAL OF CLINICAL ONCOLOGY, 1998, 16 (01) :330-337

[2]

IL-10 Signaling Blockade Controls Murine West Nile Virus Infection [J].

Bai, Fengwei ;

Town, Terrence ;

Qian, Feng ;

Wang, Penghua ;

Kamanaka, Masahito ;

Connolly, Tarah M. ;

Gate, David ;

Montgomery, Ruth R. ;

Flavell, Richard A. ;

Fikrig, Erol .

PLOS PATHOGENS, 2009, 5 (10)

[3]

Interleukin-10 determines viral clearance or persistence in vivo [J].

Brooks, David G. ;

Trifilo, Matthew J. ;

Edelmann, Kurt H. ;

Teyton, Luc ;

McGavern, Dorian B. ;

Oldstone, Michael B. A. .

NATURE MEDICINE, 2006, 12 (11) :1301-1309

[4]

IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection [J].

Brooks, David G. ;

Ha, Sang-Jun ;

Elsaesser, Heidi ;

Sharpe, Arlene H. ;

Freeman, Gordon J. ;

Oldstone, Michael B. A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (51) :20428-20433

[5]

Brooks DG, 2008, J EXP MED

[6]

Anti-interleukin 10 receptor monoclonal antibody is an adjuvant for T helper cell type 1 responses to soluble antigen only in the presence of lipopolysaccharide [J].

Castro, AG ;

Neighbors, M ;

Hurst, SD ;

Zonin, F ;

Silva, RA ;

Murphy, E ;

Liu, YJ ;

O'Garra, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (10) :1529-1534

[7]

Papillomavirus virus like particle-based therapeutic vaccine against human papillomavirus infection related diseases: Immunological problems and future directions [J].

Chen, Jiezhong ;

Ni, Guoying ;

Liu, Xiao Song .

CELLULAR IMMUNOLOGY, 2011, 269 (01) :5-9

[8]

IL-10 signalling blockade at the time of immunization inhibits Human papillomavirus 16 E7 transformed TC-1 tumour cells growth in mice [J].

Chen, Shu ;

Wang, Xiongfei ;

Wu, Xiaolian ;

Wei, Ming Q. ;

Zhang, Bin ;

Liu, Xiaosong ;

Wang, Yuejian .

CELLULAR IMMUNOLOGY, 2014, 290 (01) :145-151

[9]

CHISARI FV, 1995, ANNU REV IMMUNOL, V13, P29, DOI 10.1146/annurev.iy.13.040195.000333

[10]

Improved Dendritic Cell-Based Immunization Against Hepatitis C Virus Using Peptide Inhibitors of Interleukin 10 [J].

Diaz-Valdes, Nancy ;

Manterolal, Lorea ;

Belsue, Virginia ;

Riezu-Boj, Jose I. ;

Larrea, Esther ;

Echeverria, Itziar ;

Llopiz, Diana ;

Lopez-Sagaseta, Jacinto ;

Lerat, Herve ;

Pawlotsky, Jean-Michel ;

Prieto, Jesus ;

Lasarte, Juan J. ;

Borras-Cuesta, Francisco ;

Sarobe, Pablo .

HEPATOLOGY, 2011, 53 (01) :23-31

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