DExD/H-box proteins and their partners: helping RNA helicases unwind

被引：175

作者：

Silverman, E

Edwalds-Gilbert, G

Lin, RJ

机构：

[1] City Hope Natl Med Ctr, Beckman Res Inst, Grad Sch Biol Sci, Div Mol Biol, Duarte, CA 91010 USA

[2] Claremont Coll, Wm Keck Sci Ctr, Claremont, CA 91711 USA

来源：

GENE | 2003年 / 312卷

关键词：

RNA-dependent ATPases; helicase cofactors; RNA metabolism; RNA processing;

D O I：

10.1016/S0378-1119(03)00626-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Members of the DExD/H-box family of RNA helicases are involved in many processes and complexes within the cell. While individual DExD/H helicase family members have been studied extensively, the mechanisms through which helicases affect multiprotein complexes are just beginning to be investigated. Because RNA helicases are both highly conserved and numerous in the cell, study of RNA helicase recruitment and modulation by cofactors is necessary for understanding the mechanisms of helicase action in vivo. This review will focus on cofactor-mediated regulation of helicase target specificity and activity. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：1 / 16

页数：16

相关论文

共 150 条

[1] The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several US-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein [J].

Achsel, T ;

Ahrens, K ;

Brahms, H ;

Teigelkamp, S ;

Lührmann, R .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (11) :6756-6766

[2] A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase [J].

Akileswaran, L ;

Taraska, JW ;

Sayer, JA ;

Gettemy, JM ;

Coghlan, VM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (20) :17448-17454

[3] A PROTEIN REQUIRED FOR SPLICING GROUP-I INTRONS IN NEUROSPORA MITOCHONDRIA IS MITOCHONDRIAL TYROSYL-TRANSFER RNA-SYNTHETASE OR A DERIVATIVE THEREOF [J].

AKINS, RA ;

LAMBOWITZ, AM .

CELL, 1987, 50 (03) :331-345

[4] The 3′ to 5′ degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3′ to 5′ exonucleases of the exosome complex [J].

Anderson, JSJ ;

Parker, R .

EMBO JOURNAL, 1998, 17 (05) :1497-1506

[5]

[Anonymous], 1999, The RNA World

[6] SLU7 AND A NOVEL ACTIVITY, SSF1, ACT DURING THE PRPL6-DEPENDENT STEP OF YEAST PRE-MESSENGER-RNA SPLICING [J].

ANSARI, A ;

SCHWER, B .

EMBO JOURNAL, 1995, 14 (16) :4001-4009

[7] G-patch: a new conserved domain in eukaryotic RNA-processing proteins and type D retroviral polyproteins [J].

Aravind, L ;

Koonin, EV .

TRENDS IN BIOCHEMICAL SCIENCES, 1999, 24 (09) :342-344

[8] The MEP-1 zinc-finger protein acts with MOG DEAH box proteins to control gene expression via the fem-3 3′ untranslated region in Caenorhabditis elegans [J].

Belfiore, M ;

Mathies, LD ;

Pugnale, P ;

Moulder, G ;

Barstead, R ;

Kimble, J ;

Puoti, A .

RNA, 2002, 8 (06) :725-739

[9] Role for a bidentate ribonuclease in the initiation step of RNA interference [J].

Bernstein, E ;

Caudy, AA ;

Hammond, SM ;

Hannon, GJ .

NATURE, 2001, 409 (6818) :363-366

[10] Wheat germ translation initiation factor eIF4B affects eIF4A and eIFiso4F helicase activity by increasing the ATP binding affinity of eIF4A [J].

Bi, XP ;

Ren, JH ;

Goss, DJ .

BIOCHEMISTRY, 2000, 39 (19) :5758-5765

← 1 2 3 4 5 6 7 8 9 10 →