Novel, lipophilic derivatives of 2,5-dideoxy-2,5-imino-D-mannitol (DMDP) are powerful β-glucosidase inhibitors

被引：38

作者：

Wrodnigg, TM

Withers, SG

Stütz, AE

机构：

[1] Graz Univ Technol, Glycogrp, Inst Organ Chem, A-8010 Graz, Austria

[2] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 08期

基金：

奥地利科学基金会;

关键词：

D O I：

10.1016/S0960-894X(01)00126-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel derivatives of the D-glucosidase inhibitor 2,5-dideoxy-2,5-imino-D-mannitol bearing lipophilic aliphatic or aromatic amides attached to C-l have been found to inhibit P-glucosidase from Agrobacterium sp. in the nanomolar range. One of them, a coumarin derivative. ranks amongst the most active compounds in the class of reversible glycosidase inhibitors of the iminoalditol type. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1063 / 1064

页数：2

共 10 条

[1]

[Anonymous], 1994, ANGEW CHEM, V106, P1858

[2] ISOFAGOMINE, A POTENT, NEW GLYCOSIDASE INHIBITOR [J].