Epigallocatechin-3-gallate induces apoptosis and cell cycle arrest in HTLV-1-positive and -negative leukemia cells

被引：40

作者：

Harakeh, S. ^{[1
]}

Abu-El-Ardat, K. ^{[1
]}

Diab-Assaf, M. ^{[1
]}

Niedzwiecki, A. ^{[3
]}

El-Sabban, M. ^{[2
]}

Rath, M. ^{[3
]}

机构：

[1] Amer Univ Beirut, Dept Biol, Beirut 110236, Lebanon

[2] Amer Univ Beirut, Dept Human Morphol, Beirut 110236, Lebanon

[3] Dr Rath Res Inst, Santa Clara, CA USA

来源：

MEDICAL ONCOLOGY | 2008年 / 25卷 / 01期

关键词：

apoptosis; Human T-cell Lymphotrophic Virus-1 (HTLV-1); epigallocatechin-3-gallate (EGCG); p53; p21; transforming growth factor (TGF);

D O I：

10.1007/s12032-007-0036-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The objective of this study is to evaluate the efficacy of epigallocatechin gallate against ATL cells. The anti-proliferative and pro-apoptotic effects of EGCG were evaluated in HTLV-1-positive and -negative cells. EGCG exhibited a marked decrease in proliferation of ATL cells at 96 h of treatment. The results indicated that TGF-alpha was down-regulated whereas levels of TGF-beta 2 increased. Cell cycle distribution analysis revealed an increase in cells in the pre-G(1) phase which was confirmed by ELISA. The results on proteins showed an up-regulation of p53, Bax and p21 protein levels while the levels of Bcl-2 alpha were down-regulated.

引用

页码：30 / 39

页数：10

共 51 条

[1] Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor κB in cancer cells versus normal cells [J].