Regiospecific thermal C-acylation of imidazo [1,2-a] pyridines via an N-acylimidazolium intermediate

被引：13

作者：

Chayer, S ^{[1
]}

Schmitt, M ^{[1
]}

Collot, V ^{[1
]}

Bourguignon, JJ ^{[1
]}

机构：

[1] Fac Pharm, CNRS, ERS 655, Lab Pharmacochim Commun Cellulaire, F-67401 Illkirch Graffenstaden, France

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 52期

关键词：

acylation; imidazole; iminium salt; reaction under pressure;

D O I：

10.1016/S0040-4039(98)02322-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Direct acylation of imidazo [1,2-a] pyridines in a sealed tube at 130 degrees C and without catalyst gave various 3-acyl derivatives in satisfactory yields. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：9685 / 9688

页数：4

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