Preferential solvation of a tetrapeptide by trifluoroethanol as studied by intermolecular NOE

被引：61

作者：

Díaz, MD ^{[1
]}

Berger, S ^{[1
]}

机构：

[1] Univ Leipzig, Inst Analyt Chem, D-04103 Leipzig, Germany

来源：

MAGNETIC RESONANCE IN CHEMISTRY | 2001年 / 39卷 / 07期

关键词：

NMR; (HNMR)-H-1; (FNMR)-F-19; intermolecular nuclear Overhauser effect; HOESY; DPFGSE; trifluoroethanol; peptides; preferential solvation;

D O I：

10.1002/mrc.859

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Homonuclear and heteronuclear intermolecular NOE measurements were applied to study the solvation of a short model tetrapeptide, NAc-Ser-Phe-Val-Gly-OMe, dissolved in water, in trifluoroethanol (TFE) and in mixtures of both. Site specificity of homonuclear NOEs between water and different protons of the peptide was proved. Preferential solvation of the peptide by TFE in water-TFE mixtures was demonstrated by a significant decrease in water-peptide interaction and a concomitant buildup of heteronuclear NOE between the fluorine atoms of TFE and the peptide. Copyright (C) 2001 John Wiley & Sons, Ltd.

引用

页码：369 / 373

页数：5

共 24 条

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