DNA methylation profiling reveals a predominant immune component in breast cancers

被引：188

作者：

Dedeurwaerder, Sarah ^{[1
]}

Desmedt, Christine ^{[2
]}

Calonne, Emilie ^{[1
]}

Singhal, Sandeep K. ^{[2
]}

Haibe-Kains, Benjamin ^{[2
,3
]}

Defrance, Matthieu ^{[1
]}

Michiels, Stefan ^{[2
]}

Volkmar, Michael ^{[1
]}

Deplus, Rachel ^{[1
]}

Luciani, Judith ^{[1
]}

Lallemand, Francoise ^{[2
]}

Larsimont, Denis ^{[4
]}

Toussaint, Jerome ^{[2
]}

Haussy, Sandy ^{[2
]}

Rothe, Francoise ^{[2
]}

Rouas, Ghizlane ^{[2
]}

Metzger, Otto ^{[2
]}

Majjaj, Samira ^{[2
]}

Saini, Kamal ^{[2
]}

Putmans, Pascale ^{[1
]}

Hames, Gerald ^{[5
]}

van Baren, Nicolas ^{[6
]}

Coulie, Pierre G. ^{[5
]}

Piccart, Martine ^{[7
]}

Sotiriou, Christos ^{[2
]}

Fuks, Francois ^{[1
]}

机构：

[1] Univ Libre Bruxelles, Fac Med, Lab Canc Epigenet, Brussels, Belgium

[2] Univ Libre Bruxelles, Inst Jules Bordet, Breast Canc Translat Res Lab JC Heuson, Brussels, Belgium

[3] Univ Libre Bruxelles, Machine Learning Grp, Dept Comp Sci, Brussels, Belgium

[4] Inst Jules Bordet, Dept Pathol, B-1000 Brussels, Belgium

[5] Catholic Univ Louvain, de Duve Inst, B-1200 Brussels, Belgium

[6] Ludwig Inst Canc Res, Brussels Branch, Brussels, Belgium

[7] Univ Libre Bruxelles, Inst Jules Bordet, Dept Med, Brussels, Belgium

来源：

EMBO MOLECULAR MEDICINE | 2011年 / 3卷 / 12期

关键词：

breast cancer; DNA methylation; epigenetics; epigenomics; microenvironment; GENE-EXPRESSION PROFILES; POPULATION; CARCINOMAS; SIGNATURES; METHYLOME; SUBTYPES; OPINION;

D O I：

10.1002/emmm.201100801

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Breast cancer is a molecularly, biologically and clinically heterogeneous group of disorders. Understanding this diversity is essential to improving diagnosis and optimizing treatment. Both genetic and acquired epigenetic abnormalities participate in cancer, but the involvement of the epigenome in breast cancer and its contribution to the complexity of the disease are still poorly understood. By means of DNA methylation profiling of 248 breast tissues, we have highlighted the existence of previously unrecognized breast cancer groups that go beyond the currently known expression subtypes. Interestingly, we showed that DNA methylation profiling can reflect the cell type composition of the tumour microenvironment, and in particular a T lymphocyte infiltration of the tumours. Further, we highlighted a set of immune genes having high prognostic value in specific tumour categories. The immune component uncovered here by DNA methylation profiles provides a new perspective for the importance of the microenvironment in breast cancer, holding implications for better management of breast cancer patients.

引用

页码：726 / 741

页数：16

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