Restoration of skin pigmentation after deep partial or full-thickness burn injury

被引：41

作者：

Dai, Niann-Tzyy ^{[1
]}

Chang, Hsin-I ^{[2
]}

Wang, Yi-Wen ^{[3
]}

Fu, Keng-Yen ^{[1
]}

Huang, Tai-Chun ^{[1
]}

Huang, Nien-Chi ^{[1
]}

Li, Jhen-Kai ^{[1
]}

Hsieh, Pai-Shan ^{[1
]}

Dai, Lien-Guo ^{[4
]}

Hsu, Chao-Kuei ^{[1
]}

Maitz, Peter K. ^{[5
]}

机构：

[1] Natl Def Med Ctr, Triserv Gen Hosp, Dept Surg, Div Plast & Reconstruct Surg, 325,Sect 2,Cheng Kung Rd, Taipei 114, Taiwan

[2] Natl Chiayi Univ, Dept Biochem Sci & Technol, Chiayi, Taiwan

[3] Natl Def Med Ctr, Dept Biol & Anat, Taipei, Taiwan

[4] Taipei Med Univ, Shuang Ho Hosp, Dept Orthoped, Taipei, Taiwan

[5] Concord Repatriat Gen Hosp, Burns & Reconstruct Surg Unit, Concord, NSW 2139, Australia

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2018年 / 123卷

关键词：

Hyperpigmentation; Hypopigmentation; Burn injury; Melanocyte; Keratinocyte; Hair follicle; MELANOCYTE STEM-CELLS; KERATINOCYTE TRANSPLANTATION PROCEDURE; TISSUE-ENGINEERED SKIN; HAIR-FOLLICLES; MELANOSOME TRANSFER; CUTANEOUS SCARS; STABLE VITILIGO; BETA-CATENIN; REPIGMENTATION; MIGRATION;

D O I：

10.1016/j.addr.2017.10.010

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Significant skin pigmentation changes occur when patients suffer deep burn injuries. These pigmentation disorders may cause not only cosmetic and psychological issues, but more importantly it increases the risk of skin cancer or photoaging. Severe burns significantly effect on the process of repigmentation as the pigmentation is tightly regulated by cell proliferation and differentiation of melanocytes and melanocyte stem cells which are housing in the epidermis and hair follicles of the skin. In the present review, we discuss the possible mechanisms to replenish the melanocytes from the healthy epidermis and hair follicles surrounding burn wounds. The molecular mechanisms of skin repigmentation following healing of bum injuries includes the differentiation of melanoblasts into melanocytes, the distribution and responses of melanocytes and melanocyte stem cells after burn injury, and the regulation of melanin production. We also reviewed advanced therapeutic strategies to treat pigmentation disorders, such as convectional surgery, laser, UV treatment and emerging concepts in skin tissue engineering. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：155 / 164

页数：10

共 97 条

[1]

Next generation human skin constructs as advanced tools for drug development [J].