Human embryonic stem cells: preclinical perspectives

被引：29

作者：

Deb, Kaushik Dilip ^{[1
]}

Sarda, Kanchan ^{[1
]}

机构：

[1] Manipal Inst Regenerat Med, Embryon Stem Cell Program, Bangalore 560071, Karnataka, India

来源：

JOURNAL OF TRANSLATIONAL MEDICINE | 2008年 / 6卷 / 1期

关键词：

D O I：

10.1186/1479-5876-6-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

Human embryonic stem cells (hESCs) have been extensively discussed in public and scientific communities for their potential in treating diseases and injuries. However, not much has been achieved in turning them into safe therapeutic agents. The hurdles in transforming hESCs to therapies start right with the way these cells are derived and maintained in the laboratory, and goes up-to clinical complications related to need for patient specific cell lines, gender specific aspects, age of the cells, and several post transplantation uncertainties. The different types of cells derived through directed differentiation of hESC and used successfully in animal disease and injury models are described briefly. This review gives a brief outlook on the present and the future of hESC based therapies, and talks about the technological advances required for a safe transition from laboratory to clinic.

引用

页数：8

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