Oxidative stress status during exposure to propofol, sevoflurane and desflurane

被引:124
作者
Allaouchiche, B
Debon, R
Goudable, J
Chassard, D
Duflo, F
机构
[1] Hop Hotel Dieu, Dept Anesthesiol & Intens Care, F-69288 Lyon 02, France
[2] Hop Edouard Herriot, Dept Biochem, Lyon, France
关键词
D O I
10.1097/00000539-200110000-00036
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
We evaluated the circulating and lung oxidative status during general anesthesia established with propofol, sevoflurane, or desflurane in mechanically ventilated swines. Blood samples and bronchoalveolar lavage fluid (BAL) specimens were respectively performed via an internal jugular vein catheter and a nonbronchoscopic BAL for baseline oxidative activity measurements: malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GPX). A 4-h general anesthesia was then performed in the three groups of 10 swine: the Propofol group received 8 mg(.)kg(-1.)h(-1) of IV propofol as the sole anesthetic; the Desflurane group received 1.0 minimum alveolar concentration of desflurane; and the Sevoflurane group received 1.0 minimum alveolar concentration of sevoflurane. We observed significantly larger levels of MDA in plasma and BAL during desflurane exposure than with the other anesthetics. We also observed smaller concentrations of circulating GPX and alveolar GPX We found a significant decrease for MDA measurements in the plasma and the pulmonary lavage during propofol anesthesia. We also found larger values of GPX measurements in the serum and the pulmonary lavage. No significant changes were observed when animals were exposed to sevoflurane. No significant changes were found for circulating concentrations of SOD during exposure to all anesthetics. In this mechanically ventilated swine model, desflurane seemed to induce a local and systemic oxidative stress, whereas propofol and sevoflurane were more likely to have antioxidant properties.
引用
收藏
页码:981 / 985
页数:5
相关论文
共 19 条
[1]  
BALDWIN SR, 1986, LANCET, V1, P11
[2]   Antioxidant status and glutathione metabolism in peripheral blood mononuclear cells from patients with chronic hepatitis C [J].
Boya, P ;
de la Peña, A ;
Beloqui, O ;
Larrea, E ;
Conchillo, M ;
Castelruiz, Y ;
Civeira, MP ;
Prieto, J .
JOURNAL OF HEPATOLOGY, 1999, 31 (05) :808-814
[3]   The effect of propofol on oxidative stress in platelets from surgical patients [J].
De la Cruz, JP ;
Zanca, A ;
Carmona, JA ;
de la Cuesta, FS .
ANESTHESIA AND ANALGESIA, 1999, 89 (04) :1050-1055
[4]   The in vitro effects of propofol on tissular oxidative stress in the rat [J].
De la Cruz, JP ;
Sedeño, G ;
Carmona, JA ;
de la Cuesta, FS .
ANESTHESIA AND ANALGESIA, 1998, 87 (05) :1141-1146
[5]   EXPIRED BREATH HYDROGEN-PEROXIDE IS A MARKER OF ACUTE AIRWAY INFLAMMATION IN PEDIATRIC-PATIENTS WITH ASTHMA [J].
DOHLMAN, AW ;
BLACK, HR ;
ROYALL, JA .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1993, 148 (04) :955-960
[6]   DECREASED ANTIOXIDANT STATUS AND INCREASED LIPID-PEROXIDATION IN PATIENTS WITH SEPTIC SHOCK AND SECONDARY ORGAN DYSFUNCTION [J].
GOODE, HF ;
COWLEY, HC ;
WALKER, BE ;
HOWDLE, PD ;
WEBSTER, NR .
CRITICAL CARE MEDICINE, 1995, 23 (04) :646-651
[7]   A MULTIVARIATE-ANALYSIS OF THE RISK OF PULMONARY COMPLICATIONS AFTER LAPAROTOMY [J].
HALL, JC ;
TARALA, RA ;
HALL, JL ;
MANDER, J .
CHEST, 1991, 99 (04) :923-927
[8]   Expression of genes for proinflammatory cytokines in alveolar macrophages during propofol and isoflurane anesthesia [J].
Kotani, N ;
Hashimoto, H ;
Sessler, DI ;
Yasuda, T ;
Ebina, T ;
Muraoka, M ;
Matsuki, A .
ANESTHESIA AND ANALGESIA, 1999, 89 (05) :1250-1256
[9]   LOSS OF ALVEOLAR MACROPHAGES DURING ANESTHESIA AND OPERATION IN HUMANS [J].
KOTANI, N ;
LIN, CY ;
WANG, JS ;
GURLEY, JM ;
TOLIN, FP ;
MICHELASSI, F ;
LIN, HS ;
SANDBERG, WS ;
ROIZEN, MF .
ANESTHESIA AND ANALGESIA, 1995, 81 (06) :1255-1262
[10]   Volatile anesthetics augment expression of proinflammatory cytokines in rat alveolar macrophages during mechanical ventilation [J].
Kotani, N ;
Takahashi, S ;
Sessler, DI ;
Hashiba, E ;
Kubota, T ;
Hashimoto, H ;
Matsuki, A .
ANESTHESIOLOGY, 1999, 91 (01) :187-197