Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: annotated tables

被引:74
作者
Nakamura, M
Sundberg, JP
Paus, R
机构
[1] Univ Hamburg, Hosp Eppendorf, Dept Dermatol, D-20246 Hamburg, Germany
[2] Jackson Lab, Bar Harbor, ME 04609 USA
关键词
hair cycle; knockout; sebaceous gland; targeted mutant mice; transgenic mouse;
D O I
10.1034/j.1600-0625.2001.100601.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Numerous transgenic, targeted mutagenesis (so-called knockouts), conditional (so-called "gene switch") and spontaneous mutant mice develop abnormal hair phenotypes. The number of mice that exhibit such abnormalities is increasing exponentially as genetic engineering methods become routine. Since defined abnormalities in hair follicle morphogenesis, cycling and/or structure in such mutant mice provide important clues to the as yet poorly understood functional roles of many gene products, it is useful to summarize and classify these mutant mice according to their hair phenotype. This review provides a corresponding, annotated table of mutant mice with hair abnormalities, classifying the latter into 6 categories, 1) abnormally low number of hair follicles, 2) disorders of hair morphogenesis, 3) of hair follicle cycling, 4) of hair follicle structure 5) of sebaceous gland structure, and 6) hair growth disorders as a consequence of immunological abnormalities. This annotated table should serve as a useful source of reference for anyone who is interested in the molecular controls of hair growth, for investigators who are looking for mouse models to explore or compare the functional activities of their gene of interest, and for comparing the hair phenotype of newly generated mouse mutants with existing ones.
引用
收藏
页码:369 / 390
页数:22
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